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EC number: 248-471-3 | CAS number: 27458-94-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Irritating to skin. Based on test data for the material.
Potential to cause serious eye damage. Based on test data for the material.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
Skin
Three skin irritation studies in rabbits have been undertaken.
In the key study, Isononanol (0.5 ml) was applied to the shaved skin of three rabbits under semi-occluded dressings for 4 hours. Dermal reactions were assessed using the Draize method 1, 24, 48 and 72 hours after removal of the dressings, and on Days 6, 8,10 and 14. The mean score for erythema at 24, 48 and 72 hours was 2.67 for each animal, and for oedema 2.67 for two animals and 3.0 for the third. The skin was dry, cracked and hardened, with scab formation, sloughing and new skin, amongst the three animals, during Days 8 to 14. In a second skin irritation study in rabbits using 24 -hour occluded exposure, Isononanol was similarly found to be irritant to intact skin.
In a third, supporting study, rabbits were subjected to a 4-hour exposure to isononanol via a semi-occlusive dermal application. Dermal reactions were scored for erythema and edema according to the method of Draize at 45 minutes, 24, 48, and 72 hours and 7 days post patch removal. All animals exhibited some signs of erythema and edema within 48 hours post patch removal. Except for one animal, all signs of dermal irritation were resolved within 7 days. The mean skin irritation scores between 24 and 72 hours were: erythema 1.83 and edema 0.22.
The key study was conducted to OECD acute irritation test guidelines, although not to GLP.
Eye
Three eye irritation studies in rabbits have been undertaken.
In the key study, Isononanol (0.1 ml) was instilled into the right eye of three rabbits. Responses to treatment were assessed using the Draize method 1, 24, 48 and 72 hrs after instillation and again on Days 6, 8, 10, 14, 17 and 21. Easily discernible areas of corneal opacity, reddening of the iris and diffuse beefy-red and slight or obvious swelling of the conjunctivae were observed amonst all animals. Corneal opacity and reddening of the iris persisted in one animal on Day 21. In a second eye irritation study with Isononanol, instilled into one eye of six rabbits, comparable irritation and persistance were observed.
In a third, supporting study, 6 rabbits had their left eye instilled with 0.1 ml of isononanol and were evaluated for signs of eye irritation at 1, 24, 48 and 72 hours and 7 days post exposure according to the method of Draize. Slight signs of irritation were noted within 1 hour post exposure, but these effects were resolved by the seven day observation point. Mean eye irritation scores between 24 and 72 hours were: cornea score 0.83, iris score 0.63, and conjunctival redness 1.42.
The key study was undertaken to OECD acute irritation test guidelines, although not to GLP.
Effects on skin irritation/corrosion: irritating
Effects on eye irritation: highly irritating
Justification for classification or non-classification
In one of the two skin irritation studies, the mean scores for erythema and oedema for all three animals exceeded the classification threshold for irritancy, and in one of the two eye irritation studies, one animal had changes to the cornea and iris that persisted to Day 21.
Isononanol is therefore classified as irritant to skin and has the potential to cause serious eye damage, according to the general classification and labeling requirements for dangerous substances and preparations (Directive 67-548-EEC) and the classification, labeling and packaging (CLP) regulation (EC) No 1272/2008
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