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EC number: 247-668-1 | CAS number: 26402-26-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Remarks:
- toxicity control from ready biodegradability study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data based on the inhibition control of a ready biodegradability guideline study. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2017).
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guideline 301 F (Ready Biodegradability: Manometric Respirometry Test)
- Version / remarks:
- July 1992
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Landesamt für Umwelt Baden-Württemberg, Germany
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 164 mL of the test item stock solution with 48.1 mg/L and a pH of 7.5 and 21.0 mg of the reference substance were added into the toxicity control vessel (corresponding to a concentration of 200 mg/L* COD). - Test organisms (species):
- activated sludge of a predominantly domestic sewage
- Details on inoculum:
- - Source of inoculum/activated sludge: municipal wastewater treatment plant AZV Breisgauer Bucht (predominantly domestic wastewater), sampling date of activated sludge: 26 July 2022,
- Preparation of inoculum for exposure: The activated sludge was washed twice with tap water by settling the sludge, decanting the supernatant and re-suspending the sludge. The sludge was aerated at ambient temperature until use.
- Concentration of sludge: 30 mg d.s./L
- Dry solids concentration: 4.27 g/L (drying at 105°C for 5 hours)
- Water filtered: no - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 14 d
- Remarks on exposure duration:
- Overall exposure was 28 d but the inhibition effect is evaluated after 14 d.
- Test temperature:
- 21.3 – 21.5°C
- pH:
- 7.5
- Details on test conditions:
- TEST CONDITIONS
- Composition of medium: according to the guideline 301 F
- Solubilising agent: none
- Test temperature: 21.3 – 21.5°C throughout the whole study and therefore within the required range of 22 ± 2°C
- pH: 7.5 (at the beginning and termination of test)
- pH adjusted: The pH of the mineral medium was 7.7 and was therefore adjusted to 7.5 with HCl. After preparation of test solutions, no pH adjustment was needed (pH: 7.5)
- Aeration of dilution water: yes, at least half an hour
- Susspended solids concentration: 30 mg d.s./L
TEST SYSTEM
- Culturing apparatus: OxiTop® (WTW / Xylem)
- Method used to create aerobic conditions: inoculum was aerated until use (see details on inoculum and medium/test solutions were prepared under oxic conditions)
- Measuring equipment: Sensomat (AQUALYTIC®)
- Test performed in closed vessels: yes
- Test performed in open system: no
- Details of trap for CO2 if used: bottles were equiped with rubber quiver inserts for NaOH pellets, which absorb the carbon dioxide produced.
SAMPLING
- Sampling frequency and method: Every 112 minutes, the current pressure was measured and stored by each measuring head.
- Sterility check if applicable: not applicable
- Sample storage before analysis: no
CONTROL AND BLANK SYSTEM
- Inoculum blank: 3 replicates (only inoculum)
- Reference substance: 3 replicates (concentration corresponding to 99.8 mg COD/L)
- Toxicity control: 1 replicate (48.1 mg/L test item and 21 mg reference substance corresponding to a concentration of 200 mg/L COD) - Reference substance (positive control):
- yes
- Remarks:
- acetic acid, sodium salt
- Duration:
- 14 d
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 48.1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- other: BOD measurements and subsequent calculation of chemical oxygen demand
- Remarks on result:
- other: Result of toxicity control from ready biodegradability test
- Details on results:
- The degradation of the toxicity control after 14 days was >25%. Therefore, the test item had no inhibitory effect on the inoculum according to the criterion of the guideline OECD 301 F.
- Results with reference substance (positive control):
- The reference compound sodium acetate reached the pass level of 60% COD within 5 days.
Reference
Since more than 25% degradation occurred in the toxicity control after 14 d (48.9 on Day 4 and >80% on Day 12), the substance is with high probability not toxic to aquatic microorganisms. The test item concentration in the toxicity control of 48.1 mg/L can be used as NOEC value for the toxicity to aquatic microorganisms.
Description of key information
NOEC (14 d) ≥ 48.1 mg/L (nominal, toxicity control of OECD 301 F)
Key value for chemical safety assessment
Additional information
Since no studies on the toxicity to aquatic microorganisms are available a ready biodegradability study is used to derive a NOEC for the toxicity to aquatic microorganisms. If a compound degrades well in a ready biodegradability test or does not inhibit the degradation of a positive control at a certain concentration, this concentration can be used as a NOEC value. This approach is in accordance with the Guidance on information requirements and chemical safety assessment (Chapter R.7b: Endpoint specific guidance, ECHA 2017).
A substance can be assumed to be not inhibitory to aquatic microorganisms, if in the toxicity control of a ready biodegradation test, more than 25% degradation based on oxygen demand (BOD/ThOD) occurred within 14 days (OECD guideline 301). For Octanoic acid, monoester with glycerol (CAS 26402-26-6) a biodegradation test according to the OECD guideline 301 F is available (and GLP). The test includes a toxicity control, which contains 48.1 mg/L of Octanoic acid, monoester with glycerol and 21 mg/L of the reference material acetic acid, sodium salt (corresponding to 199 mg/L COD). The toxicity control attained 48.9% biodegradation on Day 4 and >80% on Day 12 of incubation. Hence, the substance is not considered toxic to aquatic microorganisms in the toxicity control and the test item concentration of 48.1 mg/L (nominal) can be used as NOEC.
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