Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Data from acute oral and acute dermal toxicity studies with structural analogous substances revealed no toxic effects up to the limit dose of 2000 mg/kg bw following oral and dermal application. Thus, the oral LD50 was > 2000 mg/kg bw and the dermal LD50 was > 2000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Please refer to IUCLID Section 13.
Reason / purpose for cross-reference:
read-across source
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw
Quality of whole database:
Well described GLP compliant study conducted to recognized international test guidelines.

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
Please refer to IUCLID Section 13.
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw
Quality of whole database:
Well described GLP compliant study conducted to recognized international test guidelines.

Additional information

Acute oral toxicity of MHHPA following a single oral administration was assessed from data available for the structural analogue 4-MHHPA. Acute dermal toxicity was investigated for structural analogues HHPA and MTHPA. Read across was justified as comparable chemical and toxicological properties for all substances were assumed. The studies were performed in rats and rabbits in accordance with EU test methods and OECD guidelines or similar test methods. No mortality or significant clinical signs occurred up to the limit dose of 2000 mg/kg bw. Based on the available data on read across substances the corresponding LD50 values for acute oral and dermal toxicity of MHHPA were in each case > 2000 mg/kg bw.

Justification for classification or non-classification

Based on the results obtained in acute toxicity studies, MHHPA was not classified or labelled for acute toxicity according to Regulation (EC) No 1272/2008 (CLP).