Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
toxicity to aquatic algae and cyanobacteria
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
REPORTING FORMAT FOR THE ANALOGUE APPROACH
See attached reporting format.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
72 h
Dose descriptor:
EC50
Effect conc.:
18.45 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
(analogue substance)
Basis for effect:
growth rate
Remarks on result:
other: (Based on read-across approach from an analogue)
Key result
Duration:
72 h
Dose descriptor:
NOEC
Effect conc.:
3 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Remarks:
(analogue substance)
Basis for effect:
growth rate
Remarks on result:
other: (Based on read-across approach from an analogue)
Details on results:
Based on the experimental results obtained with the analogue substance butanone oxime (72h EC50 =16 mg/L, NOEC = 2.60 mg/L ), the read-across approach is applied and the 72h EC50 and NOEC for butan-2-one O,O',O''-(methylsilanetriyl)oxime were calculated to be 18.45 mg/L and 3.00 mg/L respectively.
Validity criteria fulfilled:
not applicable
Conclusions:
Based on read-across approach from experimental results on analogue butanone oxime, the 72h-EC50 and 72h-NOEC based on algae growth rate for butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be 18.45 mg/L and 3.00 mg/L respectively.
Executive summary:

An Algal Growth Inhibition Test was performed on analogue substance butanone oxime by the Japanese Ministry of the Environment in accordance with OECD TG 201. The 72h-EC50 and 72h-NOEC based on algae (Selenastrum capricornutum) growth rate was determined to be 16 mg/L and 2.6 mg/L respectively. Based on these results the read-across approach was performed and the 72h -EC50 and 72h-NOEC based on algae growth rate for butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be 18.45 mg/L and 3.00 mg/L respectively.

Description of key information

Key study: Read-across approach from experimental results on analogue butanone oxime: The 72h-EC50 and 72h-NOEC based on algae growth rate for butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be 18.45 mg/L and 3.00 mg/L respectively.

Key value for chemical safety assessment

EC50 for freshwater algae:
18.45 mg/L
EC10 or NOEC for freshwater algae:
3 mg/L

Additional information

Key study: Read-across approach from analogue butanone oxime:

Based on the read-across approach from experimental results on analogue butanone oxime (test method OECD 201, 72h-EC50 = 16 mg/L and 72h-NOEC = 2.6, based on algae growth rate), the algae 72h -EC50 and 72h-NOEC for butan-2-one O,O',O''-(methylsilanetriyl)oxime was determined to be 18.45 mg/L and 3.00 mg/L (basis for effect: growth rate) respectively.