Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-033-0 | CAS number: 20780-48-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 2006 - February 2007
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Remarks:
- no CoA, data on vapor pressure lacking to conclude relevance for test system
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Sampling method: Just before the start of the test duplicate samples were taken from the test and control medium without Daphnids. After 48 hours duplicate samples were taken from the test and control medium without Daphnids to confirm stability of the substance in water.
- Sample storage conditions before analysis: All samples were deep-frozen (at about -20 °C) immediatly after sampling. - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: A supersaturated suspension with a loading rate of 100 mg/L was prepared by mixing 100.2 mg test substance into 1000 mL test water. The dispersion was treated with ultrasonification for 15 minutes and was stirred on a magnetic stirrer at room temperature in the dark for 24 hours to dissolve the maximum amount of test substance in the test water. The stirring period of 24 hours was based on the results of the pre-test which showed that the solution equilibrium was reached after this time. After stirring 24 hours the saturated dispersion was filtered through a membrane filter (Schleicher & Schuell, Type NC45, pore size 0.45µm) just before the start of the test. The undiluted filtrate of the dispersion was used as test medium. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: water flea
- Strain/clone: Straus (defined by supplier as clone 5)
- Source: supplied by University of Sheffield/UK in 1992.
- Age of parental stock: 6 - 24 hours
- Feeding during test: No
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 2.5 mmol/L = 250 mg/L as CaCO3
- Test temperature:
- 20 °C
- pH:
- 7.9 - 8.0
- Dissolved oxygen:
- 8.2 - 8.6
- Nominal and measured concentrations:
- Nominal: 100 mg/L
Analytical: 0.09 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: 100 mL glass beakers
- Fill volume: 50 mL
- Aeration: The test water was aered prior to the start of the study until oxygen saturation was reached. During the study the test water was not aered.
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
- Biomass loading rate: 1 Daphnid/10 mL
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstructed test water containing: CaCl2 * H2O (294 mg/L), MgSO4 * 7H2O (123 mg/L), NaHCO3 (65 mg/L), KCl (5.8 mg/L)
- Alkalinity: 0.8 mmol/L
- Ca/mg ratio: 4:1 (based on molarity)
OTHER TEST CONDITIONS
- Adjustment of pH:
- Photoperiod: 16 hour light to 8 hour dark with 30 minute transition period
- Light intensity: approximately 570 and 740 lux.
EFFECT PARAMETERS MEASURED:
Observations were made 24 and 48 hours after exposure for immobility.
VEHICLE CONTROL PERFORMED: not applicable, no solvent used
- Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate, tested June 2006
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 0.09 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Remarks on result:
- other: Substance was tested up to solubility limit. 100 mg/L was the nominal dose
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.09 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Remarks on result:
- other: Substance was tested up to solubility limit. 100 mg/L was the nominal dose
- Details on results:
- The analytical measured test item concentration in the analyzed test medium samples (the undiluted filtrate of the supersatured dispersion) was 0.53 mg/L at the start of the test. In this test medium, the concentration found at the end of the test was below LOQ of the analytical method (LOQ=0.03 mg/L). The mean measured test item concentration (calculated as the average overall measurements in the undiluted filtrate) was 0.09 mg/L.
In the control and at the loading rate of 100 mg/L (mean measured 0.09 mg/L) no immobilized test organisms were observed during the test period of 48 hours.
The 48-hour NOEC and the 48-hour EC0 of the test substance were determined to be at least the loading rate of 100 mg/L. The 48 hour EC50 and the 48-hour EC100 were clearly higher than the loading rate of 100 mg/L. These values could not be quantified, since the test item had no toxic effect on the daphnids up to the highest test item concentration that could be dissolved in water.
No remarkable observations were made concerning the test medium. The test medium was a clear solution throughout the whole test duration. - Results with reference substance (positive control):
- The test result of June 2006 (48-hour EC50: 0.67 mg/L) showed that the sensitivity of the test organisms was within historical range of the RCC laboratory (48-hour EC50 from 1996: 0.53 -1.1 mg/L)
- Validity criteria fulfilled:
- yes
- Conclusions:
- Under the conditions of the test, the substance was not acute aquatic toxic up to its solubility limit.
- Executive summary:
An acute aquatic toxicity test was performed according to OECD TG 202 and in compliance with GLP. 20 Daphnia Magna (4 replicates, 5 organisms per test vessel) were exposed in a static system to the maximum concentration solvable in water 0.09 mg/L (mean analytical concentration). The laboratory positive control was within the historical range and no remarkable observations were made concerning the test medium. Observations regarding mobility of the Daphnids were made at 24 and 48 hours. The 48-hour NOEC and the 48-hour EC0 of the test substance were determined to be at least the loading rate of 100 mg/L. The 48 hour EC50 and the 48-hour EC100 were clearly higher than the loading rate of 100 mg/L. These values could not be quantified, since the test item had no toxic effect on the daphnids up to the highest test item concentration that could be dissolved in water. Under the conditions of the test, the substance was not acute aquatic toxic up to its solubility limit.
Reference
Description of key information
An acute aquatic toxicity test was performed according to OECD TG 202 and in compliance with GLP. 20 Daphnia Magna (4 replicates, 5 organisms per test vessel) were exposed in a static system to the maximum concentration solvable in water 0.09 mg/L (mean analytical concentration). The laboratory positive control was within the historical range and no remarkable observations were made concerning the test medium. Observations regarding mobility of the Daphnids were made at 24 and 48 hours. The 48-hour NOEC and the 48-hour EC0 of the test substance were determined to be at least the loading rate of 100 mg/L. The 48 hour EC50 and the 48-hour EC100 were clearly higher than the loading rate of 100 mg/L. These values could not be quantified, since the test item had no toxic effect on the daphnids up to the highest test item concentration that could be dissolved in water. Under the conditions of the test, the substance was not acute aquatic toxic up to its solubility limit.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.