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EC number: 231-113-5 | CAS number: 7440-03-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because a long-term aquatic toxicity study on invertebrates is available
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- The test performance does not represent a standardized method; the test performance lacks also documentation. The there was a large variation of age at test initiation (1-11 days). The results are therefore not considered to be reliable to cover the endpoint for acute aquatic toxicity. Results might be used as an indicator for the toxicity range of several metal species.
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- As many metals as possible were tested in each experiment. Depending on the test results, the concentration of each metal was either increased (if nontoxic) or decreased (if toxic) by a factor of 10 in the next experiment. Once the toxic range was bracketed, intermediate concentrations (i.e., 3.15-fold higher or lower) were tested. This procedure was repeated until each metal was tested at least twice at a concentration resulting in < 25% survival, at a concentration resulting in > 75% survival, and at all intermediate concentrations, relative to controls. Only data from experi-ments with > 80% control survival were used. Using this pro-cedure made it possible to cover the toxic range of a much larger number of metals than would have been possible if each metal had been tested sequentially in a concentration series.
- GLP compliance:
- no
- Analytical monitoring:
- yes
- Details on sampling:
- Filtered samples were collected using disposable filter cartridges attached to polypropylene syringes, acidified with high purity nitric or hydrochloric acid, and stored in 14 ml capacity Falcon polypropylene disposable round bottom tubes with snap caps.
Water samples were preserved in the same acid and concentration that was supplied with the metal standards.
Metal analysis were performed by inductively coupled plasma mass spectrometry by the National Laboratory for Environmental Testing. Quality assurance/quality control methodology included calibration checks at the initiation and completion of each run, and verification and drift standards.
Certified reference standards also were included when available.
Also included were machine blanks, sample blanks, control samples, and acid controls - Vehicle:
- no
- Test organisms (species):
- other: Hyalella azteca
- Details on test organisms:
- - Common name: Hyalella azteca
- Origin: Valens Conservation Area (ON, Canada)
- Age at study initiation: 1-11 days
- Feeding during test: yes
- Food type:cotton fish food flakes
- Amount:at the start of the test: 2.5 mg per test container; an additional 2.5 mg of food was provided midweek - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 7 d
- Hardness:
- 1) Tap water (Lake Ontario): 124 mg CaCO3/L
2) Soft water consisting of 10% culture medium and 90% deionised water: 18 mg CaCO3/L - Test temperature:
- 24-25°C
- Nominal and measured concentrations:
- Concentration range (nominal/measured) not specifically reported
- Details on test conditions:
- TEST SYSTEM
- Test vessel: polyethylene cups (snap-top specimen containers), 500-mL with 400 mL of test water
- Aeration: no
- Renewal rate of test solution: no
- No. of organisms per vessel: 15
- No. of vessels per concentration (replicates): 2 to 5 (no exact number given)
- No. of vessels per control (replicates): 3
TEST MEDIUM / WATER PARAMETERS
- Culture medium different from test medium: Two sets of experiments were run, one inLake Ontario Tap water (1) and another in soft water consisting of 10% culture medium and 90% deionised water (2).
OTHER TEST CONDITIONS
- Adjustment of pH: yes
- Photoperiod: 16:8 light:dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): lethality - Reference substance (positive control):
- no
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- 0.25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Basis for effect:
- mortality
- Remarks on result:
- other: Soft water; 95% CL: 0.177-0.354
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- 0.026 mg/L
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Basis for effect:
- mortality
- Remarks on result:
- other: Soft water; 95% CL: 0.016-0.043
- Duration:
- 7 d
- Dose descriptor:
- LC50
- Effect conc.:
- 1.938 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- element
- Basis for effect:
- mortality
- Remarks on result:
- other: Tap water; 95% CL: 1.692-2.219
Referenceopen allclose all
Description of key information
A study on the long-term toxicity according to OECD guideline 211 is available for niobium metal.
Key value for chemical safety assessment
Additional information
In accordance with column 2 of Annex VII and VIII of Regulation (EC) No 1907/2006, short-term studies for the aquatic ecotoxicity do not need to be conducted if there are mitigating factors indicating that aquatic toxicity is unlikely to occur, for instance if the substance is highly insoluble in water. However, a study on the long-term toxicity according to OECD guideline 211 is available for niobium metal, showing no chronic effects to Daphnia magna up to the highest concentration tested. The 21 d NOEC values for the reproductive performance, immobilisation, growth (adult length at test termination), development rate and intrinsic rate r of population increase were determined as ≥10 mg/L (nominal). Therefore, it is concluded that niobium is not chronically toxic to aquatic invertebrates.
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