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EC number: 217-288-0 | CAS number: 1800-91-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 03 October 2012 to 30 January 2013
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Remarks:
- Study performed according to the OECD Testing Guideline and GLP compliant.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- This deviation does not affect the outcome of the study
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 1.61 mg/L
- Temp.:
- 20 °C
- pH:
- 5.5
- Conclusions:
- The water solubility of 1,6-Divinylperfluorohexane is 1.61 mg/L at 20°C and at pH 5.5.
- Executive summary:
The determination of the water solubility of 1,6-Divinylperfluorohexane was performed according to Method A.6 "Water solubility"of Commission Regulation (EC) No 440/2008 of 30 May 2008 and the Method 105 "Water Solubility" of OECD Guideline and GLP.
The solubility in water of a test item is specified by the saturation mass concentration of the test item in water at a given temperature.
Preliminary non GLP test was performed to determine the amount of the sample and the necessary time to achieve the saturation of the test item in the solution. According to these preliminary tests, the water solubility of the test item resulted to be lower than 0.01 g/L.
The flask method was preferred at the column elution method (normally recommended for the substance with a water solubility lower than 0.01 g/L) for the following reasons:
- The test item is a liquid, so not easily distributed on the quartz sand used as inert support;
- The mechanical action through the coloumn could allow to a run off of test item from the quartz sand with formation of fine dispersion of undissolved test item drops in the aqueous fraction collected.
In order to avoid an overestimation of the water solubility value the flask method was preferred.
The test item was dissolved in water at a temperature somewhat above the test temperature (30°C) and stirred 24hours, 48 hours or 72 hours. The test solutions were then cooled and kept at the test temperature during 24 hours.
Subsequently, the mass concentration of the test item in the aqueous solution, which must not contain any undissolved particles, is determined by a suitable analytical method.
The analytical method used for the test was the GC coupled with an ECD detector.
From the obtained experimental value, using starting solutions obtained with about 1 g of test item and 100 mL of water, it can be concluded the the water solubility of 1,6-Divinylperfluorohexane sample is 1.61 µg/mL at 20°C.
Reference
Validity criteria:
The quality criteria of the A.6 method were verified (RSD% over three values is <15%)
Table 1 : Linear calibration curve:
WSS1: 50.65 ng/mL {Peak area) | WSS2: 101.30 ng/mL (Peak area) | WSS3: 253.25 ng/mL (Peak area) | |
1st injection | 4776520 | 8127456 | 14888200 |
2nd injection | 4563240 | 7933376 | 14360560 |
Mean | 4669880 | 8030416 | 14624380 |
Delta | 213280 | 194080 | 527640 |
Delta % | 4.57% | 2.42% | 3.61% |
y=mx+ q | Parameter m (slope) | Parameter q (intercept) | Parameter R2(correlation) |
47810 | 2650746 | 0.99088 |
Table 2 : water solubility results
Flask | As(*) | Cs(1) (ng/mL) | Ds | Water Solubility (ng/mL) | Mean (µg/mL) |
A1 - 24h | 6475500 | 80.00 | 20.0 | 1599.97 | 1.60 |
A2 - 24h | 6462304 | 79.72 | 20.0 | 1594.45 | |
B1 - 48h | 6535588 | 81.26 | 20.0 | 1625.11 | 1.63 |
B2 - 48h | 6551440 | 81.59 | 20.0 | 1631,74 | |
C1 - 72h | 6483630 | 80.17 | 20.0 | 1603.37 | 1.61 |
C2 - 72h | 6503528 | 80.58 | 20.0 | 1611.70 | |
Mean value: : | 1.61 | ||||
Standard deviation (S.D.): | 0.02 | ||||
Relative Standard Deviation (RSD%): | 0.99% |
(*) Mean of two injections
(1) Quantification with the linear calibration curve
Description of key information
The water solubility of the test substance was determined in a study performed with the Shake flask method according to recognized guidelines (OECD 105, EU Method A.6) and under GLP. The water solubility is determined to be 1,61 mg/L at 20°C and at pH 5.5.
Key value for chemical safety assessment
- Water solubility:
- 1.61 mg/L
- at the temperature of:
- 20 °C
Additional information
The water solubilty of the test item was investigated in one GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.
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