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EC number: 214-527-0 | CAS number: 1141-38-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Low acute acute oral toxicity to rats was observed in a limit test.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
- GLP compliance:
- yes
- Limit test:
- yes
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 33 % (w/v) - Doses:
- 5 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured
- Clinical signs:
- other: No clinical signs were noted during clinical observation
- Other findings:
- No morphological findings were noted
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item revealed low acute oral toxicity to rats in a limit test.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
- Quality of whole database:
- sufficient
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Rats received March 16, 1981 and final report issued July 9, 1981
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OPPTS 870.1300 (Acute inhalation toxicity)
- GLP compliance:
- yes
- Test type:
- traditional method
- Limit test:
- yes
- Specific details on test material used for the study:
- 2,6-naphthalene dicarboxylic acid
- Species:
- rat
- Strain:
- CD-1
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- The albino rats used on this sudy were of Sprague-Dawley derived srain (Charles River CD) received from the Chrales River Breeding laboratories (Portage, MI) on March 16, 1981.TEST ANIMALS
- Source: Charles River Breeding laboratories (Portage, MI)
- Males and Females (nulliparous and non-pregnant)
- Age at study initiation: Males 54 days old; Females 61 days old
- Weight at study initiation: 245 g ± 10.4 g; Females 206 g ± 4.4 g
- Fasting period before study: none
- Housing: During quarantine period the rats were group-caged in suspended wire-mesh cages, segregated by sex. during ht eexposure and post-exposure periods the rats were caged individually and identified with individual monel metal ear tags.
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): Controlled
- Temperature, humiditity (%): not stated specifically, but according to Guide for the Care and Use of Laboratory Animals (DHEW No. N.I.H. 74-23, 1974
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: To: April 1, 1981 to April 15, 1981 - Route of administration:
- inhalation: dust
- Type of inhalation exposure:
- whole body
- Vehicle:
- clean air
- Mass median aerodynamic diameter (MMAD):
- 7.6 µm
- Geometric standard deviation (GSD):
- 1.95
- Remark on MMAD/GSD:
- Andersen 8 stage cascade impactor
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Glass and stainless steel chambers.
- Exposure chamber volume: 160 L
- Method of holding animals in test chamber: Individual caged in suspended wire mesh cages
- Source and rate of air: from HVAC system, 80-90 L/min
- Method of conditioning air: filtered before entering dust generator
- System of generating particulates/aerosols: IRDC dust generator
- Method of particle size determination: Andersen 8 stage cascade impactor
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution:
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.):
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Remarks on duration:
- Acutal exposure time 248 min (4.13 h)
- Concentrations:
- Single exposure at maximum air concentration sustainable
- No. of animals per sex per dose:
- 5 males and 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Daily observations, weights prior to exposure and at 7 and 14 days
- Necropsy of survivors performed: yes, gross pathology - Statistics:
- Mean and standard deviations for atmosphere concentration, particle size, and body weights
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50 cut-off
- Effect level:
- 0.73 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- none
- Clinical signs:
- other: During exposure, all of the exposed animals were observed to have dyspnea. In for of the 10 animals this condition was also observed for the first day or two in the 14-day postexposure observation period.
- Body weight:
- All animals gained weight during the study. Males starting mean weight 245 g and end mean weight 321 g. Females starting mean weight 206 g and ending weight 249 g.
- Gross pathology:
- The only finding was the gross observation of varying shades of red areas on the lungs of three male rats.
- Other findings:
- None
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No animals died during the in life phase of the study, during or after exposure to 0.73 µg/L of 2,6-naphthalene dicarboxylic acid. As such, the LC50 is above 0.73 µg/L.
- Executive summary:
The study consisted of a single group of five male and five female albino rats. This group was exposed for approximately 4 hours to a dust aerosol atmosphere containing 0.73 mg/L of 2,6 -naphthalene dicarboxylic acid with an aerodynamic diameter of 7.6 µM with a geometric standard deviation of 1.95. All animlas were observed during the exposure and postexposure period. body weights were recorded prior to exposure and at 7- and 14 -days postexposure. The only pharmacotoxic sign noted during and after exposure was dyspnea. All animals gained weight and survived the until the scheduled sacrifice, where they underwent a gross necropsy wherein all major organs in the abdominal and thoraic cavities were observed for macroscopic abnormalities. The only notable finding during gross necropsy as red areas in the lungs of three male rats.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 730 mg/m³ air
- Quality of whole database:
- sufficient
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- not specified
- GLP compliance:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): 0.9 % saline solution
TEST MATERIAL
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Constant volume or concentration used: yes/no
- For solids, paste formed: yes/no - Duration of exposure:
- 24 h
- Doses:
- 2 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- no mortality occured
- Clinical signs:
- other: mild transient dermal irritation (erythema) occured in two rabbits following unwrapping
- Gross pathology:
- Only one female rabbit revealed red areas on lungs at necropsy, all other rabbits occured normal.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item revealed low dermal toxicity to rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
- Quality of whole database:
- sufficient
Additional information
Justification for classification or non-classification
Based on the available data, the test item does not have to be classified as for acute oral toxicity, acute dermal toxicity or acute inhalation toxicity according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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