Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-745-8 | CAS number: 693-21-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
DEGDN was not mutagenic for Salmonella in a mammalian microsome mutagenicity assay using strains TA97, TA98, TA100 or TA102 in the presence and absence of S9 metabolic activation over a 1000-fold DEGDN concentration range. However, in a forward mutation assay using the point mutation at the thymidine kinase locus in the mouse lymphoma cell (L5178Y TK=/-), DEGDN was shown to be a weak mutagen independent of S9 metabolic activation.
There were no apparent TNG-induced mutagenic effects in the cytogenetic analyses of cells from dogs and rats and in the dominant lethal mutation study in rats for the substance TNG.
Short description of key information:
Two in vitro mutagenicity studies were found for DEGDN:
- gene mutation study in bacteria
- gene mutation study in mammalian cells
No reference to in vitro cytogenicity study in mammalian cells or in vitro micronucleus was found. Due to the results of in vitro and in vivo mutagenicity studies were used for read-across.
One reference to in vitro chromosome abberation test in chinese hamster chromosomes was found, but only in form the summary in document Summary of SIDS results for TNG. The series of cytogenic studies in dogs and rats in the chronic study were conducted for TNG. In addition, dominant lethal mutation studies were also conducted.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
