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EC number: 236-691-2 | CAS number: 13465-08-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: One generation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1995
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Study was not conducted to a standardised guideline or reproduction test. Insufficient controls.
Data source
Reference
- Reference Type:
- publication
- Title:
- A reproductive toxicity screen of a liquid propellant (LP) formulation administered in the drinking water of Sprague-Dawley rats.
- Author:
- Kinkead E.R., Wolfe R.E., Salins S.A., Latendresse J.R., Caldwell D.J., Miller C.R.
- Year:
- 1 995
- Bibliographic source:
- Journal of the American College of Toxicology. 14(2):173
Materials and methods
- Principles of method if other than guideline:
- Male and female Sprague Dawley rats were exposed to a liquid propellant containing hydroxylammonium nitrate and triethanolammonium nitrate at doses of 20, 100 or 200 mg/100 ml in their drinking water. After 14 days, the animals were mated and treatment continued for a total of 90 days. Half of the male rats were sacrificed after mating, remaining animals were sacrificed at the end of the study period.
- GLP compliance:
- not specified
- Limit test:
- yes
Test material
- Reference substance name:
- Hydroxylammonium nitrate
- EC Number:
- 236-691-2
- EC Name:
- Hydroxylammonium nitrate
- Cas Number:
- 13465-08-2
- Molecular formula:
- H3NO.HNO3
- IUPAC Name:
- hydroxylammonium nitrate
- Test material form:
- not specified
- Details on test material:
- The test material was a liquid propellant containing hydroxylammonium nitrate and trethanolammonium nitrate (specific percentage of each chemical not stated).
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- water
- Details on exposure:
- No data.
- Details on mating procedure:
- No data.
- Analytical verification of doses or concentrations:
- not specified
- Details on analytical verification of doses or concentrations:
- No data.
- Duration of treatment / exposure:
- Animals were administered hydroxylammonium nitrate for 14 days prior to mating and maintained on the treatment for 90 days in total.
- Frequency of treatment:
- Ad libitum.
- Details on study schedule:
- No data.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20, 100, 200 mg LP/100 ml
Basis:
nominal in water
Specific concentration of hydroxylammonium nitrate not determined.
- No. of animals per sex per dose:
- No data.
- Control animals:
- not specified
- Details on study design:
- No data.
- Positive control:
- No data.
Examinations
- Parental animals: Observations and examinations:
- No data.
- Oestrous cyclicity (parental animals):
- No data
- Sperm parameters (parental animals):
- No data.
- Litter observations:
- No data.
- Postmortem examinations (parental animals):
- No data.
- Postmortem examinations (offspring):
- No data.
- Statistics:
- No data.
- Reproductive indices:
- No data.
- Offspring viability indices:
- No data.
Results and discussion
Results: P0 (first parental generation)
General toxicity (P0)
- Clinical signs:
- effects observed, treatment-related
- Description (incidence and severity):
- Male animals showed a treatment related decreases in RBC, HGB, MCV and MCH.
- Body weight and weight changes:
- not specified
- Food consumption and compound intake (if feeding study):
- not specified
- Organ weight findings including organ / body weight ratios:
- effects observed, treatment-related
- Other effects:
- effects observed, treatment-related
- Description (incidence and severity):
- Test substance intake: A treatment related decrease in water consumption was noted at the onset of the study and continued through to study termination.
Reproductive function / performance (P0)
- Reproductive function: sperm measures:
- effects observed, treatment-related
- Description (incidence and severity):
- A decrease in the concentration of motile sperm was observed in the high dose rats at sacrifice.
- Reproductive performance:
- no effects observed
Details on results (P0)
Male rats sacrificed after mating showed a treatment related splenomegaly and decreases in RBC, HGB, MCV and MCH. At the highest dose male rats had a decrease in the concentration of motile sperm.
There were no differences between the treated animals and control animals in gestation index, the length of gestation or male to female pup ratio.
Effect levels (P0)
- Dose descriptor:
- NOAEL
- Remarks:
- Specific dose of hydroxylammonium nitrate not determined
- Effect level:
- 200 mg/L drinking water
- Sex:
- male/female
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Results: F1 generation
General toxicity (F1)
- Mortality / viability:
- no mortality observed
- Body weight and weight changes:
- no effects observed
Details on results (F1)
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- A liquid propellant containing hydroxylammonium nitrate and triethanolammonium nitrate caused splenomegaly in male rats after 14 days treatment. These animals also displayed treatment related decreases in RBC, HGB, MCV and MCH. At the highest dose, male rats showed a decrease in the concentration of motile sperm. There were no maternal or pup effects. A reproductive NOAEL of 20 mg LP/l can be derived based on male fertility. However as the specific concentration of of hydroxyammonium nitrate in the liquid propellant was not reported an specific NOAEL for the chemical can not be derived.
- Executive summary:
Male and female Sprague Dawley rats were exposed to a liquid propellant containing hydroxylammonium nitrate and triethanolammonium nitrate at doses of 20, 100 or 200 mg/100 ml in their drinking water (specific concentration of hydroxylammonium nitrate in the liquid propellant was not stated). After 14 days, the animals were mated and treatment continued for a total of 90 days. Half of the male rats were sacrificed after mating, remaining animals were sacrificed at the end of the study period. There was a treatment related decrease in drinking water consumption over the study period, although there were no effects in either the dams or pups. Male rats sacrificed after mating displayed splenomegaly and alterations in blood parameters. At the highest dose, male rats showed lower concentrations of motile sperm. By this study design hydroxylammonium nitrate is considered to be a reproductive toxicant although the reliability of this study is considered to be not reliable.
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