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Diss Factsheets
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EC number: 207-866-0 | CAS number: 498-66-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Ames Test
Norbornene was tested in a reverse gene mutation assay (Ames test) in bacteria (S. typhimuriumTA98; TA 100; TA1535; TA1537) in concentrations ranging from 0 to 5000 µg/plate in the presence and absense of mammalian metabolic activation (S9 mix induced from rat liver). The study was performed according to OECD 471 under GLP.
there was no evidence of induced mutant colonies over background. Cytotoxicity was obsevered with TA 100 at the highest concentrations of 2500 and 5000 µg/plate.
Chromosomal Aberration
In a first study (W. Müller, 1995) norbornene was assessed for its mutagenic potential in vitro in the chromosomal aberrationtest with two independant experiments with and without metabolic activation. No relevant reproducible enhancement of metaphases with aberrations over the range f the solvent control was found at any of the used concentrations. Cyctotoxicity was observed above 100 µg/ml.
In a second supporting study (A.Czich, 1997) again no increased, biologically relevant frequency of cells with structural chromosomal aberrations or polyploid metaphases could be observed. Cytotoxicity set in at and above concentrations of 150 µg/ml.
HGPRT
2 -Norbornene was tested in the intro HGPRT gene mutation assay with the V79 Chinese hamster cell line with and without metabolic activation. The test was carried out at dose levels from 10 -150 µg/ml, at higher dose levels strong cytotoxicity had been observed.
no effects judged to be of biological relevance were observed, the substance did not induce gene mutations under the experimental conditions.
Short description of key information:
2-Norbornene did not induce genetoxic effects in in vitro studies including an Ames test, two chromosomal aberration tests and one HGPRT-test on V79 Chinese hamster cells
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
no indication of gene-toxicity in any of the tests.
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