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Diss Factsheets
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EC number: 233-791-8 | CAS number: 10361-44-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- not applicable
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented publication.
Data source
Reference
- Reference Type:
- publication
- Title:
- Bismuth subcitrate nephrotoxicity
- Author:
- Sarikaya, M.; et al.
- Year:
- 2 002
- Bibliographic source:
- Nephron 90, 501-502
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: oral
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- case report, nephrotoxicity
- GLP compliance:
- no
Test material
- Reference substance name:
- Bismuth(3+) tripotassium bis[2-hydroxypropane-1,2,3-tricarboxylate]
- EC Number:
- 260-872-5
- EC Name:
- Bismuth(3+) tripotassium bis[2-hydroxypropane-1,2,3-tricarboxylate]
- Cas Number:
- 57644-54-9
- IUPAC Name:
- bismuth(3+) tripotassium bis[2-hydroxypropane-1,2,3-tricarboxylate]
- Details on test material:
- - Name of test material (as cited in study report): Bismuth subcitrate
No further details are given.
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 1
- Sex: female
- Age: 17 years
- Race: Asian
No further details are given. - Ethical approval:
- not applicable
- Route of exposure:
- oral
- Reason of exposure:
- intentional
- Exposure assessment:
- estimated
- Details on exposure:
- The girl had taken 25 tablets containing 300 mg bismuth subcitrate (total 7.5 g).
- Examinations:
- - Urine analysis: yes
- Haematology: yes; laboratory examination of blood urea nitrogen (BUN), serum creatinine, uric acid , serum glutamic-oxaloacetic transaminase and lactic dehydrogenase.
- Other: physical examination, abdominal ultrasonography and colour doppler ultrasonography. Renal biopsy was performed. - Medical treatment:
- The patient was managed with heamodialysis via subclavian vein catheter (6 times) and metoclopramide was added to treatment for nausea and vomiting.
Results and discussion
- Clinical signs:
- After ingestion of bismuth subcitrate, the girl noticed a progressive decrease in urine output. She was admitted to emergency room with complains of nausea, vomiting and anuria.
- Results of examinations:
- - Urine analysis: Urine examination showed ph 6.0, density 1020, protein 300 mg/dL, glucose 1000 mg/dL, 5-6 RBC and 3-4 WBC/hpf.
- Haematology: Laboratory examination revealed blood urea nitrogen (BUN) 71 mg/dL, serum creatinine 12.3 mg/dL, uric acid 8.5 mg/dL, serum glutamic-oxaloacetic transaminase 85 U/L and lactic dehydrogenase 2371 U/L.
- Other: Physical examination was unremarkable except pretibial and periorbital oedema and gastric pain. Abdominal ultrasonography revealed normal kidney size; however, renal parenchymal echo was increased. Colour doppler ultrasonography revealed no thrombus in renal vein and arteries. There was no glomerular pathology. Signs of acute tubular necrosis were encounted in the proximal tubule epithelium. - Effectivity of medical treatment:
- On the 8th day of treatment, the patients urine volume was gradually increased. At that time, laboratory examination revealed BUN 91 mg/dL and creatinine 1.8 mg/dL. Urinary examination did not show any protein, erythrocyte or leukocytes.
On the 21st day she was discharged from the hospital with complete health and BUN and creatinine were within normal limits. - Outcome of incidence:
- no data
Applicant's summary and conclusion
- Conclusions:
- An overdose of bismuth subcitrate can cause renal necrosis.
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