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Diss Factsheets
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EC number: 202-863-0 | CAS number: 100-54-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: According or similar to a guideline study, with acceptable restrictions. No data is provided on substance purity.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: not stated
- Principles of method if other than guideline:
- Test material was applied to the shaved and abraded skin of rabbits and covered with an occlusive dressing for 24 hours. The material was removed, skin gently rinsed and the animals were observed for 14 days for morbidity and mortality.
- GLP compliance:
- not specified
- Remarks:
- precedes establishment of guideline
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Nicotinonitrile
- EC Number:
- 202-863-0
- EC Name:
- Nicotinonitrile
- Cas Number:
- 100-54-9
- Molecular formula:
- C6H4N2
- IUPAC Name:
- pyridine-3-carbonitrile
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Albino
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Four groups of four albino rabbits (2 male & 2 female) weighing between 2.0 and 3.0 kg each were employed in this study. All animals had their backs clipped free of hair 24 hours prior to testing. All of the animals had their backs abraded prior to dosing.
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- All rabbits were weighed and the correct amount of experiemental material was applied to the back of each animal.
- Doses:
- 0.5 gm/kg, 1.0 gm/kg, 2.0 gm/kg, 4.0 gm/kg
- No. of animals per sex per dose:
- 4 groups of 4 albino rabbits (2 male and 2 female)
- Details on study design:
- 14 day observation period
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 2 other: gm/kg
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2 - 4 other: gm/kg
- Based on:
- test mat.
- Mortality:
- One male animal died at 2.0 gm/kg. Deaths occurred between 18-36 hours for males and females (2 each) at 4.0 gm/kg
- Clinical signs:
- other: No untoward symptoms were noted at 0.5 gm/kg. At 1.0 gm/kg, the animals were depressed after 24 hours, but appeared normal by 48 hours. At 2.0 gm/kg, the animals were severely depressed, ataxic, cold and demonstrating involuntary muscle tremors by 24 hour
- Gross pathology:
- Revealed nothing remarkable
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information LD50 of male/female is > 2000 mg/kg bw. Criteria used for interpretation of results: EU
- Conclusions:
- 3-Cyanopyridine as tested in male rabbits has an acute dermal LD50 of approximately 2.0 gm/kg and an acute dermal LD50 of approximately 2.0 gm/kg - 4.0 gm/kg for female rabbits.
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