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EC number: 410-940-7 | CAS number: 60166-91-8 LACTOFTALURO
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EEC B6 Buhler test.
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Justification for non-LLNA method:
- At the time of testing LLNA was not validated
Test material
- Reference substance name:
- (S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene
- EC Number:
- 410-940-7
- EC Name:
- (S)-5-[2-(acetyloxy)propanamido]-2,4,6-triiodo-1,3-di(chloroformyl)benzene
- Cas Number:
- 60166-91-8
- Molecular formula:
- C13H8Cl2I3NO5
- IUPAC Name:
- 1-{[3,5-bis(carbonochloridoyl)-2,4,6-triiodophenyl]carbamoyl}ethyl acetate
- Test material form:
- solid: particulate/powder
1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Details on test animals and environmental conditions:
- The Dunkin Hartley albino guinea pig is the species generally recommended by the Health Authorities as the experimental model for skin sensitization studies
Supplier:
Charles River Italia S.p.A.
Via Indipendenza, 11
22050 Calco (Como)
Number:
37 animals
20 animals in the experimental group
10 animals in the negative control group
7 animals for the preliminary test
Body weight (and age):
between 436-509 g at the start of the experiment (corresponding to an age of 6 weeks)
Sex: males
Acclimattion: 10 days
Housing:
(room H12C)
2 or 3 animals/cage in an air-conditioned room.
- temperature: 22 ± 2 ° C
- air changes: about 20/h filtered on HEPA 99.97% filtres
- relative humidity: 55 ± 10%
- artificial light: 12 h cycle (7 a.m. - 7 p.m.)
- cage: wire cages (40.5x38.5x18h) with a stainless steel feeder.
The waste that dropped through the wire bottom onto removable paper was periodically disposed of.
Study design: in vivo (non-LLNA)
Induction
- Concentration / amount:
- Concentration of test material and vehicle used at induction:
a) Test substance 50% in acetone
b) Vehicle - acetone 100%
Concentration of test material and vehicle used for each challenge:
a) 50% test substance in acetone
b) 100% vehicle - acetone
Challenge
- Concentration / amount:
- Concentration of test material and vehicle used at induction:
a) Test substance 50% in acetone
b) Vehicle - acetone 100%
Concentration of test material and vehicle used for each challenge:
a) 50% test substance in acetone
b) 100% vehicle - acetone
- No. of animals per dose:
- Number of animals in test group: 20
Number of animals in negative control group: 20 - Details on study design:
- two preliminary tests were performed on March 3 and 10,1992 (shipping slips no.s 01301, 01598 and 02038 dated February 12, 21 and March 6, 1992, respectively) in order to select the maximum well tolerated concentration for the induction phase and the maximum concentration shown to be not irritating for the challenge exposure.
In the first test concentrations of 25%, 10% and 5% were assayed on three animals.
An aliquot of 0.5 ml of each test article concentration was applied to the skin of two animals with a closed patch.
Twenty-four hours after the administration, the patches were removed, and the animals observed for up to 48 h for local reactions on the skin area of the patch application. The concentrations assayed were well tolerated and not irritating.
On the basis of these results, a second test was performed using two higher concentrations, 50% and 35%, on 4 animals in order to find a possible moderate irritation. Concentrations of 50% and 35% were once more shown to be tolerated and not irritating. A concentration of 50% (w/v) was therefore used in the final test.
he test article was solubilized in acetone to obtain a 50% (w/v) test article concentration (maximum practicable concentration).
The test article formulate was prepared just before use, and protected from light (plastic tube wrapped in aluminium sheet).
Due to the type of study, analysis for stability and concentration was not performed.
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Hours after challenge:
- 6
- Group:
- test chemical
- Dose level:
- 50 %
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- None
Any other information on results incl. tables
Maximum concentration not causing irritating effects in preliminary test: 50 %
Signs of irritation during induction:
None
Other observations:
None.
Applicant's summary and conclusion
- Interpretation of results:
- other: not classified
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