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EC number: 947-155-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 19th November - 10th December, 2019
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 211 (Daphnia magna Reproduction Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: 3M FMRD, S352546
- Expiration date: 2020.05.01
- Purity: 99.7%
- Physical state: Clear and colorless liquid
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Stored at room temperature (15-25°C).
- Stability under test conditions: Due to analytical issus, stability during the test is unknown. - Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 5, 10, 20, 50, 100, 200, 500 ug/L, control and solvent control.
- Sampling method: A sample of ~20 mL was taken from excess of each test solution, media blank and acetone control for fresh solution sampling. For old media sampling, 2mL solution was sampled from each replicate of the test group and control solution, then pooled. Samples were processed and analyzed the same day as their collection. - Vehicle:
- yes
- Remarks:
- Acetone
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 0.2004 g of the test item was dissolved in 20 mL acetone and mixed to get the stock concentration of 10000 mg/L. Volumes of 0.313, 0.625, 1.25, 2.50 and 5.0 mL of the stock solution were diluted with acetone (10 mL), resulting in acetone solutions of 313, 625, 1250, 2500, 5000 mg/L in addition to the 10000 mg/L. 0.10 mL of solution was added to 1 L of test water whilst mixing by magnetic stirring for 1 hour to get nominal concentrations of 0.0313, 0.0625, 0.125, 0.25, 0.5 and 1.0 mg/L. A solvent control solution was also prepared by adding 0.10 mL acetone into 1L test water and stirred for 1 hour. Test solutions were clear.
- Concentration of vehicle in test medium: 100 uL/L - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
Common name: Water flea
- Strain/clone: Daphnia magna (Straus)
- Source: Applied Chemistry Department Pesticide Environmental Evaluation Lab of the ChinaAgricultural University
- Age of parental stock: <24 hours old
- Culture conditions: Adult daphnids were cultured in tap water treated with Aquapro Pure Water Systems. During the period preceding the test, water temperatures were 18 - 22°C, photoperiod of 16h light, 8h dark. Daphnids in the cultures were fed daily a suspension of concentrated alga suspension. Neonates were not the first brood.
- Health: The test Daphnia magna was derived from a healthy stock (i.e. showing no signs of stress such as high mortality, presence of males and ephippia, delay in the production of the first brood, discolored animals, etc.)
- Food type: Living algal cells of Chlorella sp and Desmodesmus subspicatus
- Amount: 0.1 ~ 0.2 mg C/Daphnia/day
- Frequency: Once daily - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 21 d
- Hardness:
- 160-170 mg CaCO3
- Test temperature:
- 18.2-19.8
- pH:
- 8.22-8.48
- Dissolved oxygen:
- 8.46-9.39
- Nominal and measured concentrations:
- Nominal: 0.0313, 0.0625, 0.125, 0.25, 0.5, 1.0 mg/L, blank and solvent controls.
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 200 mL glass beakers
- Fill volume: 90 mL per vessel
- Aeration: Water was aerated for more than 24 hours before use to attain dissolved oxygen saturation of at least 80% ASV. No aeration during the test.
- Renewal rate: 24 hours
- No. of organisms per vessel: One
- No. of vessels per concentration: Ten
- No. of vessels per control: Ten
- No. of vessels per vehicle control: Ten
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Tap water treated with Aquapro Pure Water System
- Total organic carbon:<2 mg/L, measured every three months.
- Particulate matter: <5 mg/L suspended solids
- Metals: All less than detection limits, except fluoride (0.31 mg/L)
- Pesticides:all less than detection limits
- Culture medium different from test medium: No
OTHER TEST CONDITIONS
- Adjustment of pH: No
- Photoperiod: 16h light, 8h dark
- Light intensity: 1025 ~ 1240 lux for cool white light
EFFECT PARAMETERS MEASURED: Effects measured during the definitive test include total number of broods per parent, mortality of parents daphnids, body length of parent daphnids, time to first brood, and total living offspring daphnid per parent. These parameters were measured daily. In addition, number of aborted eggs or dead offspring were recorded daily.
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 2-fold
- Range finding study: yes
- Test concentrations: Nominal concentrations: 0.1, 1.0 and 10 mg/L
- Results used to determine the conditions for the definitive study: In the 1.0 and 10 mg/L test group, all daphnids were dead after 6 and 2 days, respectively. Actual concentration at the 0.1 and 1.0 mg/L concentration was about 0.0633 and 0.485 mg/L for fresh media (0-hours) and below the LOD for both in old media (48-hours). - Reference substance (positive control):
- no
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.25 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Details on results:
- - Reproduction data summary in Table 2
- Time until first brood summary in Table 2, NOEC was 1.0 mg/L (nominal)
- Body Length summary in Table 2, NOEC was 1.0 mg/L (nominal)
- Broods per parent summary in Table 2, NOEC was 0.5 mg/L (nominal)
- There was no mortality in the parent animals
- Other: During the test, there were no dead offspring, aborted eggs, or male offspring.
- Mortality of control: No mortality in control Daphnids (0%), within guideline criteria
- Effect concentrations exceeding solubility of substance in test medium: No - Reported statistics and error estimates:
- Statistical analyses were performed on survival of first-generation daphnids, the number of live young, and the length and dry weight of the surviving first-generation daphnids. The F-test was used to analyze homogeneity of variance for live offspring, first brood time, total # of broods, and parental body length. Reproduction and growth (length) data were evaluated to determine significance via a one-side Student´s T-test using a 5% significance level in an EXCEL document. For body length of parent, the P-value in the F-test was <0.05, and therefore an unequal-variance T-test was done.
- Validity criteria fulfilled:
- yes
- Remarks:
- Mortality of the parent animals in the controls (0%) did not exceed 20%, mean number of living offspring in the controls (143 blank, 136 solvent) was ≥60, CV in living offspring produced per parent (14.7%, 10.3%, blank and solvent), was <25%
- Conclusions:
- 21 day NOEC = 0.25 mg/L (OECD 211) in Daphnia magna (nominal) for reproduction
- Executive summary:
The 21 day NOEC to Daphnia magna was determined in a definitive test according to OECD 211 guidelines. Nominal concentrations of 0.0313, 0.0625, 0.125, 0.25, 0.5, 1.0 mg/L, a solvent control, and a blank control were run using 1 animals per vessel (10 replicates per concentration) and acetone as a dispersant at 100 ug/L. Analytical monitoring of fresh and 24-hour-old solutions was done twice per week. A NOEC of 0.25 mg/L (nominal concentration) was determined.
This study was conducted under international guidelines and was compliant with GLP criteria. However, the analytical data for the test indicates that the NOEC value reported in this study is not reliable. Qualifying transitions for the calibration curves and qualifying transitions for old samples were out of spec. Due to failing qualitative ion criteria in many solutions and presence of interference/possible contaminations in the blank and solvent control, nearly all measured concentrations could not be relied upon. From available data in the study report, the analytical data does not confirm test substance concentration and strongly suggests the test substance was not maintained throughout the test. For these reasons the study has been deemed unreliable. Thus, these results are not considered suitable for use in Risk Assessment, Classification & Labeling, and PBT analysis.
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The target chemical (MTDID 44428 (CAM-8) CASRN 87015-11-0) and the source chemical (isooctyl acrylate (IOA) CAS 29590-42-9) are isomers that contain the same functional acrylate moiety attached to primarily C8 alkyl hydrocarbon chains (C7-C9, C8 rich for the source chemical) with variable branching. The source chemical differs from the target chemical in both the degree and position of branching of the alkyl ester group with the source chemical being branched at the terminal end of the alkyl chain while the target chemical is branched near the acrylate functional group. The acrylate group is expected to be metabolized in the same manner in both substances and the remaining alkyl chain will be metabolized and excreted via the same pathway. The source chemical and target chemical have the same molecular weight and very similar log Kow values (Target: 4.7-4.8, Source: 4.5-4.7). Similar ADME profiles are expected between the two substances as the metabolic pathway of acrylate esters has been well characterized. Acrylate and methacrylate functionalities are electrophilic and both may participate in Michael addition reactions. Metabolism is expected to occur through the same pathways, hydrolysis by carboxylesterases into two metabolites, an alcohol and
an acrylic acid moiety with minor conjugation to gluthathione. Hydrolysis is similar across the acrylate family and enhances the elimination of the chemical upon exposure (McCarthy & Witz, 1997). Studies with n-butyl acrylate and 2-ethylhexyl acrylate confirm that the acrylic acid metabolite enters aerobic oxidation and in completely metabolized to CO2 with only a minor proportion be conjugated to glutathione and excreted in the urine as a N-acetyl cysteine conjugate (Sanders, JM et. al, 19188; Gut, I, et al. 1988). The previously mentioned studies have also demonstrated that enzymatic hydrolysis kinetic constants for methacrylate and acrylate esters are similar.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
Target Chemical
The target molecule, MTDID 44428 (CASRN 87015-11-0), is a multi-constituent substance defined as the reaction mass of octan-2-yl acrylate, octan-3-yl acrylate and octan-4-yl acrylate as represented by the following structures (see attached read-across justification document). Molecular weight of the target chemical is 184.3
Source Chemical:
The source chemical, isooctyl acrylate (IOA) CAS 29590-42-9, is defined as a UVCB and is represented by the following structure (see attached read-across justification document). The average molecular weight of the source substance is ca. 184.0. The source chemical differs from the target chemical in the degree and position of branching of the alkyl ester group with the source chemical having variable methyl branching along the alkyl chain while the target chemical is branched immediately adjacent to the acrylate functional group.
Purity and Impurities :
MTDID 44428 is a multi-constituent substance and the three acrylate constituents contribute >99% of the content. There are very low levels of residual reactants and reaction side products. Isooctyl acrylate is a UVCB substance, based on the mixed-isomer nature of the material. As a UVCB substance, all components are considered part of the substance and the concept of impurities has little meaning. Acrylate ester content of IOA is >99 %, with very low levels of residual reactants and reaction side products. These non-acrylate components are substantially similar and do not impact the read-across of test results from IOA.
3. ANALOGUE APPROACH JUSTIFICATION
The target chemical and source chemical are closely related alkyl acrylate compounds. They differ slightly in the structure of the alkyl ester portion of the molecule. MTDID 44428 contains a methyl, ethyl or propyl branch at the 1-carbon of the alkyl chain portion of the molecule, which is always C8 in total. IOA may have methyl or ethyl branches at one or more positions along the alkyl ester group. The carbon chain is predominantly C8 in total with lesser contributions of C7 and C9 (C8 on average). The environmental toxicity of low molecular weight acrylate esters (aquatic mortality and immobilization) is by protein adduct formation via a Michael-type addition mechanism. In the environment, toxicity increases on a molar concentration basis with molecular weight (and concomitantly, hydrophobicity) due to increased ability of the molecule to reach its active site. The excess toxicity is mitigated in high molecular weight acrylate esters with log P > 5. The mammalian toxicity of IOA and MTDID 44428 is also based on protein adduct formation via a Michael-type addition with the acrylate groups. Both the target and source chemical are weak dermal sensitizers (section 5 in attached read-across justification and data matrix table) indicating that an equivalent mechanism of toxicity is at work for both substances based on identical functional groups and molecular weights and very similar log Kow values and water solubilities. The number of hydrophobic carbons of IOA relative to MTDID 44428 is predicted to be similar resulting in very similar octanol water partition coefficient values. This was confirmed experimentally and the log Kow for IOA is 4.5-4.7 while the log Kow for MTDID 44428 is 4.7-4.8. Additionally, IOA and MTDID 44428 have very similar water solubility at 12.44 and 14.6 mg/L, respectively. IOA is expected to be metabolized via the same hydrolytic and enzymatic pathways as MTDID 44428, forming acrylic acid and isooctanol. Similar mammalian metabolic pathways are expected for IOA and MTDID 44428 based on Sanders, et. al and Gut, et al. The source chemical and target chemical have the same molecular weight and very similar log Kow values. Similar ADME profiles are expected between the two substances as the metabolic pathway of acrylate esters has been well characterized. Acrylate and methacrylate functionalities are electrophilic and both may participate in Michael addition reactions. Metabolism is expected to occur through the same pathways, hydrolysis by carboxylesterases into two metabolites, 2an alcohol and an acrylic acid moiety with minor conjugation to gluthathione. Hydrolysis is similar across the acrylate family and enhances the elimination of the chemical upon exposure (McCarthy & Witz, 1997). Studies with n-butyl acrylate and 2-ethylhexyl acrylate confirm that the acrylic acid metabolite enters aerobic oxidation and in completely metabolized to CO2 with only a minor proportion be conjugated to glutathione and excreted in the urine as a N-acetyl cysteine conjugate (Sanders, JM et. al, 1988; Gut, I, et al. 1988). The previously mentioned studies have also demonstrated that enzymatic hydrolysis kinetic constants for methacrylate and acrylate esters are similar. As can be seen in section 5 in attached read-across justification and data matrix table, the source and target substances have very similar environmental and mammalian hazard profiles for endpoints where each substance has experimental data. This further supports the hypothesis that the target and source substances are expected to behave similarly in mammalian and environmental systems with the same mechanism of action and that read-across of the data for higher-tier endpoints is appropriate in an effort to reduce unnecessary animal testing.
4. DATA MATRIX
See 'Other Information Including Tables' or attached justification.
Supporting References
Gut, I, Vodička, Cikrt, M, Sapota, A, and Kavan, I (1988) Distribution and elimination of (14C)-2-ehtylheyxyl acrylate radioactivity in rats. Archives of Toxicology 62:346-350.
McCarty, TJ and Witz, G (1997) Structure-activity relationships in the hydrolysis of acrylate and methacrylate esters by carboxylesterase in vitro. Toxicology 116: 153-158.
Sanders, JM, Burka, LT, and Matthews, HB (1988) Metabolism and disposition of n-butyl acrylate in male Fischer rats. Drug Metabolism and Disposition 16(3): 429-434 - Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 0.065 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: NOEC for reproduction was calculated as one-half of the LOEC. 21-day NOEC (immobilization), 1.06 mg/L.
- Conclusions:
- MTDID 44428 is estimated to have a 21d NOEC=0.065 mg/L to Daphnia magna by read across from isooctyl acrylate.
- Executive summary:
The similarities between the structural, physical & chemical, toxicity, and predicted metabolic properties of the source and target substances presented above support the read-across hypothesis for long term toxicity to aquatic invertebrates. The data are adequate and reliable scientific information to support the hypothesis. Therefore, based upon the data and considerations presented in the above sections, it can be concluded that the results of the long term toxicity to aquatic invertebrates study with source substance will accurately predict the results for the target substance and are considered as adequate to fulfill the information requirement of Annex VIII, of the REACH Regulation for the target substance.
Referenceopen allclose all
Table 2. Mean Chronic Toxic Effects to Daphnia magna in Definitive Tests
Nominal conc. (mg/L) |
Mean Offspring ± Std Dev |
Mean Time to First Brood ± Std Dev (p-value) |
Mean Total Brood ± Std Dev |
Mean Body Length ± Std Dev (p-val) |
Blank control |
143±21 (-) |
8.3±0.7 (-) |
5.9±0.6 (-) |
3.31±0.29 (-) |
Solvent control |
136±14 (0.38) |
8.7±0.9 (0.29) |
5.6±0.5 (0.23) |
3.17±0.32 (0.32) |
0.0313 |
134±19 (0.81) |
8.4±0.7 (0.43) |
5.6±0.7 (1.00) |
3.16±0.32 (0.91) |
0.0625 |
132±16 (0.65) |
9.0±0.8 (0.46) |
5.5±0.7 (0.72) |
3.09±0.24 (0.52) |
0.1250 |
137±14 (0.84) |
8.9±0.9 (0.63) |
5.8±0.4 (0.36) |
3.07±0.28 (0.45) |
0.2500 |
130±19 (0.50) |
9.3±1.2 (0.22) |
5.7±0.8 (0.75) |
2.91±0.28 (0.07) |
0.5000 |
113±14** (0.002) |
9.2±1.1 (0.30) |
5.4±0.5 (0.40) |
3.06±0.15 (0.32) |
1.0000 |
107±16*** (0.0005) |
9.7±1.4 (0.08) |
5.0±0.7* (0.04) |
3.01±0.16 (0.18) |
/: Not calculated
p-value of test groups compared with the solvent control
* : there was signficant differences when p value (t-test) was below 0.05
Read-Across Data Matrix
Target substance |
Source substance |
|
CHEMICAL NAME |
Reaction mass of octan-2-yl acrylate, octan-3-yl acrylate and octan-4-yl acrylate |
Isooctyl acrylate |
CAS# |
44914-03-6 |
29590-42-9 |
Molecular formula |
C11H20O2 |
C11H20O2 (on average) |
Molecular Weight |
184.3 |
184.3 (on average) |
Melting Point |
Experimental: <-35 °C |
Experimental: < -90 °C at 1004 hPa |
Boiling Point |
Experimental: 217.6 °C (normalized). |
Experimental: 196.8 °C at 1016 hPa |
Density |
Experimental: 0.8665 at 23 °C |
Experimental: 0.885 g/cm3 at 20.0 °C |
Vapour Pressure |
Experimental: .06 hPa at 18 °C |
Experimental: 1 hPa at 20 °C |
Partition Coefficient (log KOW) |
Experimental: 4.7-4.8 |
Experimental: 4.5 - 4.7 |
Water Solubility |
Experimental: Individual isomers had solubilites of 4-5 mg/L, total was 14.6 mg/L |
Experimental: 12.44 mg/L at 23.1 °C |
|
|
|
Stability in Water |
Experimental: t1/2at 25 °C, pH 9, 37.7-116 days t1/2at 25 °C, pH 7, 137 days - not determinable t1/2at 25 °C, pH 4, 154 days - not determinable. Hydrolysis product could be detected at pH 9 but not pH 7 and 4. Half-life increased from 2-octyl < 3-octyl < 4-octyl isomers. |
Adaptation, readily biodegradable |
Aerobic Biodegradation |
Experimental: 54.7% after 28 days, biodegradation essentially stopped at day 11 (OECD 301F)
67% after 28 days. No residual material could be detected in test chambers on day 28. In abiotic control, residual test material was 4.8% of initial result (OECD 302C) |
Experimental: 93-95% after 28 days (OECD 301D) |
Bioconcentration |
|
Not bioaccumulative |
Transport and Distribution |
Experimental: Koc 630 (OECD121) |
Experimental: Koc 650-3900 (OECD121) |
Henry's Law constant |
NDA |
Experimental: 1780 Pa*m3/mol at 23.1 °C |
Acute Toxicity to Fish (P. promelasunless noted) |
NDA |
Experimental: 96-hour LC50 0.67 mg/L (OECD 202) |
Chronic Toxicity to Fish |
NDA |
Waived |
Acute Toxicity to Aquatic Invertebrates (D. magna) |
NDA |
Experimental: 48-hour EC50 0.4 mg/L (OECD 202) |
Long-Term Toxicity to Aquatic Invertebrates (D. magna) |
NDA |
Experimental: 28-day NOEC 0.065 mg/L (OECD 202 rev 1984) |
Toxicity to Algae and Aquatic Plants (P. subcapitata) |
NDA |
QSAR result. Not read across |
Toxicity to Microorganisms (activated sludge respiration) |
Experimental: 3-hour EC50 >1000 mg/L (OECD 209) |
Experimental: 3-hour EC50 >1000 mg/L (OECD 209) |
Acute Oral Toxicity |
Experimental: Rat oral LD50 > 2,000 mg/kg |
Experimental: Rat oral LD50 > 5,000 mg/kg |
Acute Dermal Toxicity |
Read-across from source: Rabbit dermal LD50 > 2,000 mg/kg |
Experimental: Rabbit dermal LD50 > 2,000 mg/kg |
Acute Inhalation Toxicity |
Read-across from source: NDA |
Experimental: NDA |
Skin Irritation |
Experimental: Irritating (GHS Cat. 2) |
Experimental: Not irritating |
Eye Irritation |
Experimental: Not Irritating |
Experimental: Not irritating |
Skin Sensitization |
Experimental: Weak sensitizer (GHS Category 1B) |
Experimental: Weak sensitizer (GHS Category 1B) |
Ames Assay |
Experimental: Non-mutagenic |
Experimental: Non-mutagenic |
in vitroChromosome Aberration |
Read-across from source: Clastogenic at cytotoxic concentrations |
Experimental: Clastogenic at cytotoxic concentrations |
in vitroMouse Lymphoma Assay |
Read-across from source: Non-mutagenic |
Experimental: Non-mutagenic |
28 Day Oral Toxicity |
Read-across from source: NOAEL = 1,000 mg/kg/day |
Experimental: NOAEL = 1,000 mg/kg/day |
90 Day Oral Toxicity |
Read-across from source: NOAEL = 600 mg/kg/day |
Experimental: NOAEL = 600 mg/kg/day |
Reproductive/Developmental Screening Study (Dermal) |
Read-across from source: NOAEL = 20% Dermal Exposure |
Experimental: NOAEL = 20% Dermal Exposure |
Prenatal Developmental Study (Oral) |
Read-across from source: NOAEL = 1,000 mg/kg/day |
Experimental: NOAEL = 1,000 mg/kg/day |
Carcinogenicity (Dermal) |
Read-Across from source: Not Carcinogenic |
Experimental: Not Carcinogenic (5% Dermal Exposure) |
Description of key information
21 day NOEC=0.065 mg/L (arith. mean) in Daphnia magna (OECD 211)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Dose descriptor:
- NOEC
- Effect concentration:
- 0.065 mg/L
Additional information
A study performed using MTDID 44428 with Daphnia magna under OECD 211 was considered unreliable due to methodological deficiences. The data gap for invertebrate acute toxicity was filled by using read across from isooctyl acrylate. The key value for acute invertebrate toxicity was a 21 day NOEC=0.065 mg/L of isooctyl acrylate to Daphnia magna, determined in a definitive test according to OECD 211 guidelines.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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