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EC number: 427-900-1 | CAS number: 198404-98-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 09 March 1998 - 03 July 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- 17 July, 1992.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.1 (Acute Toxicity for Fish)
- Version / remarks:
- December, 1992
- Deviations:
- no
- GLP compliance:
- yes
- Specific details on test material used for the study:
- JAVANOL :
Batch No. : 008825
Purity : 88.4% (sum of the two peaks)
Expiry Date : 18 February, 2000 - Analytical monitoring:
- yes
- Remarks:
- GC-FID
- Details on sampling:
- Static set-up. Samples were taken at the beginning and end of the exposure.
Further samples were taken from the solutions at 56 and 100% after all fish were dead. - Vehicle:
- yes
- Remarks:
- Acetone at maximum of 0.1 mL/L.
- Details on test solutions:
- A stock solution in acetone of JAVANOL was prepared at 100 mg/mL. Per litre of stock medium 0.1 mL of this stock was added and the solution stirred overnight. Prior to testing, this solution was filtered through a 0.2 micron filter to obtain the actual dissolved fraction. The filtrate was a clear, colourless solution. This filtrate was further diluted to prepare the final test concentrtions :
100% filtrate
56% filtrate
32% filtrate
18% filtrate
10% filtrate
Control
Solvent Control (acetone at 0.1 mL/L) - Details on test organisms:
- Carp (C. carpio)
Mean length : 2.10 +/- 0.10 cm
Mean weight : 0.25 +/- 0.06 g
Quarantined for at least 12 days post delivery
Medium : ISO Medium
Validity of Batch : Mortality during the 7 days prior to the start of the study was less than 5% - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Hardness:
- 250 mg CaCO3/L
- Test temperature:
- 20.0 to 20.7°C
- pH:
- pH range 7.6 - 8.0
- Dissolved oxygen:
- Dissolved O2 Range = 7.1 - 9.3 mgO2/L
- Nominal and measured concentrations:
- Exposure concentrations were determined at Time 0 and at the end of the exposure (96 hours) :
Filtrate % Time 0 (mg/L) 96 hour (mg/L)
100% 4.96 3.95 (at 24 hours - all fish dead)
56% 2.79 1.97 (at 24 hours - all fish dead)
32% 1.55 0.479
18% 0.840 0.181
10% 0.496 0.0784 - Details on test conditions:
- Test Duration : 96 hours
Test Type : Static
Test Vessels : 8 Litres all glass (with 5 L of test medium)
Test Medium : ISO Medium
No. of Fish : 7 fish per concentration and controls
Fish Loading : Approx. 0.35 g/L (7 fish per 5 litres)
Photoperiod : 16 hours per day of light / 8 hours dark
Aeration : No aeration
Feeding : No feeding 48 hours prior to start of test - Reference substance (positive control):
- yes
- Remarks:
- Pentachloropehnol
- Key result
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 1.02 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC0
- Effect conc.:
- 0.4 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- LC100
- Effect conc.:
- 2.3 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- Mortality observed in the different exposure concentrations at 96-hours :
Control 0%
Solvent-Control 0%
10% Filtrate (Mean Exp. 0.195 mg/L) 0%
18% Filtrate (Mean Exp. 0.390 mg/L) 0%
32% Filtrate (Mean Exp. 0.862 mg/L) 14%
56% Filtrate (Mean Exp. 2.34 mg/L) 100% (all dead by 24 hours)
100% Filtrate (Mean Exp. 4.43 mg/L) 100% (all dead by 24 hours) - Results with reference substance (positive control):
- Pentachlorophenol :
LC50 decreased from 0.16 mg/L (95% CI : 0.14 - 0.21 mg/L) at 24 hours to 0.13 mg/L (95 % CI : 0.12 - 0.17 mg/L). - Validity criteria fulfilled:
- yes
- Conclusions:
- An acute fish toxicity study was performed with Common Carp exposed to JAVANOL. The following end-points were determined, based on geometric mean measured concentrations :
96 hour LC50 = 1.02 mg/L
96 hour LC0 = 0.4 mg/L
96 hour LC100 = 2.3 mg/L
Reference
Description of key information
An acute fish toxicity study was performed with Common Carp exposed to JAVANOL. The following end-points were determined, based on geometric mean measured concentrations :
96 hour LC50 = 1.02 mg/L
96 hour LC0 = 0.4 mg/L
96 hour LC100 = 2.3 mg/L
.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 1.02 mg/L
Additional information
An acute fish toxicity study was performed with Common Carp exposed to JAVANOL. The following end-points were determined, based on geometric mean measured concentrations :
96 hour LC50 = 1.02 mg/L
96 hour LC0 = 0.4 mg/L
96 hour LC100 = 2.3 mg/L
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