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EC number: 268-820-3 | CAS number: 68140-98-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 13 April 2004
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION
- Method: Water Accommodated Fractions (WAFs) were prepared by weighing portions of the test substance on small plastics trays and subsequently transferred from the trays to 1 liter of distilled water. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna, Straus
- Source: own rearing, the original source Water Research Institute, Bratislava, Slovak Republic
- Age: < 24 h
- Feeding during test: no - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Hardness:
- 159,86 mg/L (CaCO3)
- Test temperature:
- 19.0 °C - 20.9 °C
- pH:
- 7.65 - 8.39
- Dissolved oxygen:
- 7.23 - 7.91
- Nominal and measured concentrations:
- Nominal test concentrations: 20 mg/L, 40 mg/L, 60 mg/L, 80 mg/L, 100 mg/L (WAF)
Analysis of the WAF loading of the test substance at the start and end of the definitive test (100 mg/L WAF loading of the test substance) was sufficient because of the exposure WAF loading varied less than 20 % from nominal values during the test (+16.75 %). - Details on test conditions:
- TEST SYSTEM
- Fill volume: 10 mL
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: ISO Test water [ISO 6341. (1996). Water quality – Determination of the inhibition of the mobility of Daphnia magna Straus (Cladocera, Crustacea) – Acute toxicity test. Third edition, 1996]
- Chlorine: < 10 μg/L
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16-hour light and 8-hour dark cycle.
EFFECT PARAMETERS MEASURED:
Immobilisation, measured daily
RANGE-FINDING STUDY
- Results used to determine the conditions for the definitive study: The limit test indicated that 48 h EC50 of the test substance in the test medium was lower than 100 mg/L (48 h immobilization 80 %). - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate, K2Cr2O7, Batch NoMPS-ETS-04/2011
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 73.96 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Remarks on result:
- other: WAF loading
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 69.17 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- mobility
- Remarks on result:
- other: WAF loading
- Results with reference substance (positive control):
- - Results with reference substance valid?
yes
- 48 h-EC50: 0.69 mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- In an immobilisation test on Daphnia magna according to OECD 202, the 48h- EC0 was determined to 69.17 mg/L (WAF).
- Executive summary:
The toxicity of MC A45A to Daphnia magna was determined in an immobilisation test according to OECD 202. Due to the limited water solubility of the test item, the test was therefore performed on water accommodated fractions (WAF).
Analysis of the test item performed during a limit test revealed that WAF loading varied less than 20% from nominal values.
The results of testing reference substance are consistent with literature data.
Reference
Results of the main test after 48 hours
Concentration [mg/L] |
No. of immobilized animals |
% Immobilization |
20 |
0 |
0 |
40 |
0 |
0 |
60 |
11 |
55 |
80 |
13 |
65 |
100 |
15 |
75 |
Description of key information
The effect values were obtained in a valid test according to OECD 202.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 69.17 mg/L
Additional information
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