Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 293-260-1 | CAS number: 91052-98-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Human clinical data published in peer reviewed literature. Reliability not known but contributing to weight of evidence assessment
- Justification for type of information:
- Justification for Category/Read-across approach:
See justification document for category approach and read-across to individual UVCB constituents in section 13.2.
Data source
Reference
- Reference Type:
- publication
- Title:
- A fatal case considered to be due to cardiac arrhythmia associated with butane inhalation
- Author:
- Fuke C, Miyazaki T, Arao T, Morinaga Y, Takaesu H, Takeda T and Iwamasa T
- Year:
- 2 002
- Bibliographic source:
- Legal Medicine 4, 134-138
Materials and methods
- Study type:
- clinical case study
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The case report summarises human data following exposure to butane gas.
- GLP compliance:
- no
Test material
- Reference substance name:
- Butane
- EC Number:
- 203-448-7
- EC Name:
- Butane
- Cas Number:
- 106-97-8
- Molecular formula:
- C4H10
- IUPAC Name:
- butane
- Details on test material:
- - Name of test material (as cited in study report): butane
- Physical state: gas
- Other: contents of a portable fuel canister
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 1
- Sex: male
- Age: 14 years
- Height/weight: 165 cm/44 kg
- Race: no data
- Known diseases: none - Route of exposure:
- inhalation
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
- Details on exposure:
- The boy inhaled butane gas, over a period of approximately 1 h 30 min.
- Examinations:
- - An autopsy was carried out 12 h after death
- Urine analysis: no
- Haematology: yes; fuel gases were analysed 19 h after death by headspace gas chromatography
- Lung tissue: fuel gases were analysed 19 h after death by headspace gas chromatography
- Other: brain tissue; fuel gases were analysed 19 h after death by headspace gas chromatography - Medical treatment:
- Approximately 2 h after starting to inhale butane gas, the boy collased. Ambulance crew performed cardiopulmonary resuscitation including cardioversion, but this was not successful. An electrocardiogram revealed ventricular fibrillation. Resuscitation attempts continued at hospital.
Results and discussion
- Clinical signs:
- None reported.
- Results of examinations:
- - Autopsy findings: The external jugular veins were clearly visible on the surface. No petechial haemorrhages were found in the conjunctivae. Internally, every organ was congested. No oedema was found in the larynx. Microscopic examination showed severe oedema in the lungs; no inflammatory lesions were found in any organ. Neither natural diseases nor traumatic lesions related to his death were found.
- Results of fuel gas analyses: n-Butane, isobutane and propane were detected in the blood, brain and lung. Acetone was not detected in any specimen. The concentrations of n-butane, isobutane and propane were 2.4, 0.4, 0.04 µL/mL in the blood, 3.0, 1.2, 0.04 µL/g in the brain, and 1.1, 0.3, 0.02 µL /g in the lung, respectively.
- There was no other toxicological evidence including ethanol or drugs except for lidocaine which was used for emergency medical treatment. - Outcome of incidence:
- Death occurred approximately 4 h after starting to inhale butane gas.
Applicant's summary and conclusion
- Conclusions:
- This was a fatal case considered to be due to cardiac arrhythmia associated with butane inhalation.
- Executive summary:
This was a fatal case considered to be due to cardiac arrhythmia associated with butane inhalation. If collapse comes during butane sniffing or after butane inhalation, cardiac arrhythmia should be considered as a cause of death.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.