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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 238-851-7 | CAS number: 14782-75-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Toxicity to aquatic algae and cyanobacteria
Administrative data
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 22 July 2004 to 27 January 2005.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 201 (Alga, Growth Inhibition Test)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 451-250-6
- EC Name:
- -
- Cas Number:
- 569318-35-0
- Molecular formula:
- C11 H19 Al O5
- IUPAC Name:
- Aluminium 1, 3-butanediol ethyl acetoacetate complexes
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- The substance is the Source of the read-across.
The test material hydrolyses quickly (t1/2 < 3 h). Based on advice from the UK Environment Agency, the test material was ground and stirred in diluent to allow hydrolysis, and expose test organisms to hydrolysis products.
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Smaples were taken from the control and each test group at 0 and 72 h for quantitative analysis.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- XP 338: The test material was known to rapidly hydrolyse releasing butane-1,3-diol and ethyl acetoacetate. These are water soluble, but the co-formed aluminium hydroxide is poorly soluble (1.5 mg/L at 20 °C), so the test material was filtered to remove solids that may have exerted a physical effect on the test organisms.
Test organisms
- Test organisms (species):
- Scenedesmus sp.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 72 h
Test conditions
- Test temperature:
- 24 °C
- pH:
- 7.5
- Nominal and measured concentrations:
- Nominal test concentration were 1.0, 3.2, 10, 32, 100 and 320 mg/L, besed in terms ofparent test material.
For ethyl acetoacetate: after 72 h there was a marked decline in the measured concentration. Given that stability analyses indicated that the substance was stable in culture medium over 72 h, this decline was considered to be due to adsorption to algal cells.
For butane-1,3-diol: after 72, there was a slight decline in measured concentrations. Given that stability analyses indicated that the substance was stable in culture medium over 72 h, this decline was also considered to be due to adsorption to algal cells. - Details on test conditions:
- Following a preliminary range-finding test, algae was exposed to an aqueous solution of the hydrolysed test substance for 72 h under constant illumination and shaking at 24 °C.
Samples of the algal populations were removed daily, and cell concentrations determined for each control and treatment group, using a Coulter Multisizer particle counter.
Results and discussion
Effect concentrationsopen allclose all
- Key result
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 320 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- growth rate
- Duration:
- 72 h
- Dose descriptor:
- EC50
- Effect conc.:
- 7.3 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat. (dissolved fraction)
- Basis for effect:
- biomass
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- EbC50 (72 h) 7.3 mg/L; ErC50 (0 - 72 h) >320 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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