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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation / corrosion, other
Remarks:
in vivo study already available
Type of information:
experimental study
Adequacy of study:
key study
Study period:
No dates were provided.
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967
Report date:
1967

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
Please refer to "Principles of method"
Principles of method if other than guideline:
according to BASF-internal standard
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethanol, 2-(ethenylthio)-
EC Number:
608-554-0
Cas Number:
3090-56-0
Molecular formula:
C4H8OS
IUPAC Name:
Ethanol, 2-(ethenylthio)-
Test material form:
liquid
Specific details on test material used for the study:
No specific details for test material were provided.

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
No details provided.

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
Back: no amount spezified
Ear: 2 mL were applied
Duration of treatment / exposure:
Back: 1, 5 and 15 min and 20 h
Ear: 20 h
Observation period:
8 days
Number of animals:
2 animals were used for 1, 5, and 15 min exposure.
Another 2 animals were used for 20 h exposure.
Details on study design:
TEST SITE
- Area of exposure: 2.5 X 2.5 on the back, outside of the ear

REMOVAL OF TEST SUBSTANCE
- Washing: with water
- Time after start of exposure: directly after exposure time was done.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Remarks:
1, 5, 15 min and 20 h exposure
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Remarks:
Application side: back
Irritation parameter:
edema score
Remarks:
1, 5, 15 min and 20 h exposure
Basis:
mean
Time point:
other: 8 d
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Remarks:
Application side: back
Irritation parameter:
erythema score
Remarks:
20 h exposure
Basis:
mean
Time point:
24 h
Score:
1
Max. score:
4
Reversibility:
fully reversible within: 8 d
Remarks on result:
probability of weak irritation
Remarks:
Application side: back
Irritation parameter:
erythema score
Remarks:
1, 5, 15 min exposure
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Remarks:
Application side: back
Irritation parameter:
erythema score
Remarks:
1, 5, 15 min and 20 h exposure
Basis:
mean
Time point:
other: 8 d
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Remarks:
Application side: back
Irritation parameter:
erythema score
Remarks:
20 h exposure
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Remarks:
Application side: ear
Irritation parameter:
erythema score
Remarks:
20 h exposure
Basis:
mean
Time point:
other: 8 d
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Remarks:
Application side: ear
Irritation parameter:
edema score
Remarks:
20 h exposure
Basis:
mean
Time point:
24 h
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Remarks:
Application side: ear
Irritation parameter:
edema score
Remarks:
20 h exposure
Basis:
mean
Time point:
other: 8 d
Score:
0
Max. score:
4
Remarks on result:
no indication of irritation
Remarks:
Application side: ear
Irritant / corrosive response data:
After the application of the test substance for 1, 5 and 15 min to the back no effects were detected after 24 h and 8 days.
After the application of the test substance for 20 h to the back a slight redness was detected after 24 h but was not present after 8 days.
The application of the test substance to the ear for 20 h caused no detectable effects.
Other effects:
No other local or systemic effects were observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met