Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-743-7 | CAS number: 693-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A primary irritancy study on the carbodiimides was conducted to establish sensitization and challenge concentrations and to ensure the mice would tolerate multiple days of topical exposure. This assay was a modification of the phototoxicity murine model developed by Gerberick and Ryan.**
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N'-methanetetraylbis(1-methylethylamine)
- EC Number:
- 211-743-7
- EC Name:
- N,N'-methanetetraylbis(1-methylethylamine)
- Cas Number:
- 693-13-0
- Molecular formula:
- C7H14N2
- IUPAC Name:
- (propan-2-yl)({[(propan-2-yl)imino]methylidene})amine
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- B6C3F1
- Details on test animals or test system and environmental conditions:
- Female B6C3F1 mice (4-5 weeks, 17-20 grams) were purchased from Taconic Farms (Germantown, NY) hepatitis and Sendai virus free and quarantined until 8 weeks of age. The mice were maintained on Agway Rat and Mouse Ration (NIH 031) and tap water ad libitum. The animal facility maintained a temperature between 18-26"C, a relative humidity between 40-70%, and a lightfdark cycle of 12-hour intervals throughout the experimental period.
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- other: acetone
- Controls:
- yes, concurrent vehicle
- Amount / concentration applied:
- With a pipette, 12.5 pl of the test material or vehicle was applied to both sides of each ear pinna for four consecutive days (50 pllmousdday).
- Duration of treatment / exposure:
- 4 days
- Observation period:
- Twenty-four hours (j2 hr) after the final treatment, mice were restrained and ear thickness was measured in the identical manner as pretreatment measurements
- Number of animals:
- no data
Results and discussion
In vivo
Results
- Irritation parameter:
- other: ear thickness
- Basis:
- other: The mean percent ear swelling
- Time point:
- 24 h
- Remarks on result:
- positive indication of irritation
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- It is classifed as Skin Irrit. 2 H315
- Executive summary:
Animals exposed to DIC experienced dose dependent irritation responses. For DIC, the Maximal Non-Irritating Concentration (MNC) was 3% and the Minimal Irritating Concentration (MIC) was 10%.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.