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Diss Factsheets
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EC number: 931-276-9 | CAS number: 114959-46-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
An assessment of the toxicological behaviour of the substance has been conducted to the extent that can be derived from relevant available information.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
TEST MATERIAL
The test substance comprises a purple flaky solid but is made commercially available in liquid form with a refined mineral oil. Therefore the substance was administered as a solution in the available in vivo studies.
The low vapour pressure value of the neat substance shows that it is not volatile and therefore inhalation is not a significant route of exposure. The neat substance is also not expected to undergo hydrolysis under physiological conditions. As a result, exposure to hydrolysis products, following oral ingestion, is not expected.
The test substance has a relatively high molecular weight (765 g/mol), which suggests absorption across biological membranes is unlikely to be significant. However, based on a moderately high octanol/water partition coefficient (5.32 ± 0.31 at 40 degrees Centigrade), the substance may have the potential to cross biological membranes. The available physico-chemical data on the neat substance and toxicological data on the preparation of neat substance and carrier oil were reviewed and, although the presence of carrier oil in the studies was taken into account, the assessment of toxicokinetic behaviour was based on the neat substance.
ABSORPTION
The repeat-dose oral toxicity study in rats showed that the substance is absorbed via the gastro-intestinal tract. The moderately high log octanol/water partition coefficient will also favour absorption of the substance from the gut. Publically available absorption, distribution, metabolism and excretion (ADME) data for the carrier oil shows very poor permeability across the membrane. However, signs of absorption for the test material are seen in the skin sensitisation test in guinea pigs. This may have been enhanced by the skin irritation produced by the substance since damage to the skin surface may increase penetration of the substance through the skin to some extent. Low volatility of the substance suggests that the test material would not be available for inhalation.
DISTRIBUTION
There is some evidence to suggest that the substance is distributed systemically in oral studies. The positive response in a skin sensitisation study in the guinea pig suggests that the test material gets to and binds to carrier proteins in the circulatory system. The relatively high log octanol/water partition coefficient suggests that the substance may distribute into the adipose tissue, although no evidence of accumulation in body fat is available and bioaccumulation potential is unlikely to be significant.
METABOLISM
The substance is hydrolytically stable under physiological conditions and is likely to undergo further metabolism prior to excretion. The results of the long-term oral toxicity studies show evidence of an adaptive response in the livers of rats, which is normally associated with enhanced metabolism. The results of the in vitro genotoxicity assays do not show any evidence that addition of the S9 metabolising system and hence further metabolism either enhances or diminishes the activity of the substance.
EXCRETION
There is no evidence to indicate the main route of excretion but poorly water soluble products with high molecular weight are unlikely to be excreted in the urine and biliary excretion may well be a significant route for this material. Any test material that is not absorbed will be excreted in the faeces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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