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Diss Factsheets
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EC number: 209-141-4 | CAS number: 556-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- reduced post observation time (7 days instead of 14 days). No analytical verification of test substance concentration applied.
- Principles of method if other than guideline:
- The inhalation hazard test demonstrates the toxicity of an atmosphere saturated with vapors of the volatile components of a test substance at the temperature chosen for vapor generation ( 20°C). Several groups of 3 rats per sex were sequentially exposed to the vapors, generated by bubbling 200 l/h air through a substance column of about 5 cm above a fritted disc in a glass cylinder for different time periods.
No analytical determination of the atmosphere concentrations was performed. The nominal concentration was calculated as quotient of the amount of the test substance weight loss during exposure. Group-wise documentation of clinical signs was performed over the 14 day study period. Body weight of groups was determined before the start of the study and at the end of the observation period in surviving animals. - GLP compliance:
- no
- Remarks:
- GLP was not compulsory at the time the study was conducted.
- Test type:
- other: Inhalation Hazard Test (IHT)
Test material
- Reference substance name:
- 3-methylbut-2-en-1-ol
- EC Number:
- 209-141-4
- EC Name:
- 3-methylbut-2-en-1-ol
- Cas Number:
- 556-82-1
- Molecular formula:
- C5H10O
- IUPAC Name:
- 3-methylbut-2-en-1-ol
- Details on test material:
- - Name of test substance: 3-Methylbut-2-en-1-ol (Prenol)
- Analytical purity: 95 %
- Impurities: no data given
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Average weight at study initiation: 200 - 250 g
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: The animals were exposed to atmosphere saturated with the volatile parts of the test material in the air at 20 °C.
- Details on inhalation exposure:
- Saturation of the atmosphere was generated by conducting an air stream through a substance layer of 5 cm height.
The rats were exposed to the test atmosphere for 3 and 8 hours.
Air flow was 200 l/h in the exposure chamber. - Analytical verification of test atmosphere concentrations:
- no
- Remarks on duration:
- 3 or 8 hours
- Concentrations:
- Nominal concentrations of the test substance in the atmosphere were calculated to be 10.25 mg/l (3 hrs) and 8.4 mg/l (8 hrs) by using the weight loss of test substance and the amount of air used during the exposure.
- No. of animals per sex per dose:
- 6 males and 6 females (3 hours),
3 males and 3 females (8 hours). - Control animals:
- no
- Details on study design:
- Animals were inspected for signs of pharmacologic or toxicologic effects during a 7 days post observation period. Body weight was measured before dosing. At the end of the observation period survivors were sacrificed and necropsied as were animals that died.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- other: IHT
- Effect level:
- 10.25 mg/L air
- Exp. duration:
- 3 h
- Remarks on result:
- other: No mortality
- Sex:
- male/female
- Dose descriptor:
- other: IHT
- Effect level:
- 8.4 mg/L air
- Exp. duration:
- 8 h
- Remarks on result:
- other: 1/6 animals died
- Mortality:
- No mortality was observed when 12 rats were exposed for 3 hours
Mortality in 1 animal out of 6 occurred after exposure of 8 hours during the first 24 hrs. - Clinical signs:
- other: Attempt to escape, strong secretion out of the eyes and the nose, after the exposure tremor.
- Body weight:
- The average body weight gains were within the normal limits.
- Gross pathology:
- In the animal that died, multifocal congestion of the lungs was seen, all other animals were without abnormalities.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.