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Diss Factsheets
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EC number: 253-197-2 | CAS number: 36768-62-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study performed prior to OECD guideline and GLP, but followed principles thereof. Since the test substance is a strong alkaline substance, study results can be regarded as valid.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: CFR/USA Title 16, 1500.41
- Deviations:
- no
- Principles of method if other than guideline:
- Method: other: acc. to Draize Test
- GLP compliance:
- no
- Remarks:
- prior to GLP
Test material
- Reference substance name:
- 2,2,6,6-tetramethyl-4-piperidylamine
- EC Number:
- 253-197-2
- EC Name:
- 2,2,6,6-tetramethyl-4-piperidylamine
- Cas Number:
- 36768-62-4
- Molecular formula:
- C9H20N2
- IUPAC Name:
- 2,2,6,6-tetramethylpiperidin-4-amine
- Details on test material:
- Name of test material (as cited in study report): Triacetondiamin
- Substance type: colourless liquid with low viscosity
- Physical state: liquid
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: J. Scheele, Büdrich/Westfalen, Werl, Germany
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
Temperature: 21-23°C
climated rooms
light circle dark/light: 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: abraded and intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.5 ml undiluted
- Duration of treatment / exposure:
- 24 hour(s)
- Observation period:
- 72 hours
- Number of animals:
- 6
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
- % coverage: 100
- Type of wrap if used: gauze with non irritating tape. Additionally, the whole trunk was wrapped with an impermeable rubber blanket for 24 hours to avoid evaporation of volatile substance
REMOVAL OF TEST SUBSTANCE
- Washing : not reported
- Time after start of exposure: not reported
SCORING SYSTEM: according to Draize
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 and 72 hours
- Score:
- > 8
- Max. score:
- 8
- Reversibility:
- not fully reversible within: 72 hours
- Remarks on result:
- other: irritation index could not be calculated, but in all animals (intact and abraded skin) black-coloured necrosis occurred
- Irritant / corrosive response data:
- Dry black-coloured necrosis was observed. No derivation of a primary irritation index was possible.
Any other information on results incl. tables
The extrapolation to 4-h exposure is limited: Based on current standards, the finding does not allow to conclusively assess whether reversible lesions or necrosis would result.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1C (corrosive) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Six rabbits exposed for 24 hours to 0.5 mL test substance under occlusive condition revealed black-colured necroses on the intact and abraded skin
were observed up to 72 hours after patch removal. Reversibilty of the necrosis cannot be judged because observation time was limited to 72 hours. Therefore, the substance is regarded to be corrosive.
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