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EC number: 242-999-8 | CAS number: 19370-86-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
For dilithium adipate, the EC50 (72h) based on growth rate was 23 mg/L and the NOEC was 3.2 mg/L.
For dilithium azelate, the EC50 (72h) based on growth rate was > 100 mg/L and the NOEC (72h) was 100 mg/L
For dilithium sebacate, the EC50 (72h) based on growth rate was > 100 mg/L and the NOEC (72h) was 10 mg/L .
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 23 mg/L
- EC10 or NOEC for freshwater algae:
- 3.2 mg/L
Additional information
The toxicities to algal growth were determined in GLP-compliant, static, freshwater tests (Tobor-Kaplon 2015) following OECD guideline 201. In all studies the chemical confirmation of the test substance was based on analysis of the appropriate fatty acid, lithium and the total organic carbon (TOC). The algal growth inhibition test on dilithium adipate was conducted at 1.0, 3.2, 10, 32 and 100 mg/L. The chemical analysis confirmed nominal concentrations of test substance. Based on growth rate the 72 h NOEC was 3.2 mg/L and the ErC50 was 23 mg/L dilithium adipate.
The results of the algae study for dilithium azelate were based on a second definitive study because the first study was not valid. The test concentrations were 1.0, 3.2, 10, 32 and 100 mg/L dilithium azelate. There were significant effects based on growth rate at 32 and 100 mg/L dilithium azelate but as these resulted in <10% inhibition of the algae compared with the control they were not considered to be biologically significant. The 72 h NOEC for growth rate was 100 mg/L and the ErC50 was ≥ 100 mg/L dilithium azelate based on nominal concentrations.
The dilithium sebacate study was conducted at 0.10, 0.32, 1.0, 3.2, 10, 32 and 100 mg/L. Statistically significant inhibition of growth was observed at nominal concentrations of 10 mg/L dilithium sebacate based on growth rate, however the effect was < 10% inhibition of the algae compared with the control so was considered to be biologically not significant. The 72 h NOEC based on growth rate was 10 mg/L and the ErC50 was ≥ 100 mg/L dilithium sebacate based on nominal concentrations.
In the dilithium azelate and the dilthium sebacate studies the lithium concentration was confirmed to be stable throughout the test. The concentration of the appropriate fatty acid was confirmed as stable for up to 24 hours but after 72 hours measured fatty acid concentrations were much lower (often below the limit of quantification). In both studies the fatty acid concentration was maintained in the blank test vessel without algae throughout the exposure period. It is considered that as the algal cell density is increasing in the test vessels the fatty acid is becoming associated with the algal material. The algae are therefore still exposed to the test substance throughout the test period and all endpoints are reported based on nominal test concentrations.
Overall the three test substances show low toxicity to algae. The most sensitive results are based on the dilithium adipate study and these are used as the basis of the risk assessment.
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