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EC number: 241-012-8 | CAS number: 16941-92-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- not stated
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Not to current international guidleines, with significant deviations from the protocol. For example no revertant data provided, no metabolic activation, and no controls used.
Data source
Reference
- Reference Type:
- publication
- Title:
- Rec assay and mutagenicity studies on metal compounds.
- Author:
- Kanematsu N, Hara M and Kada T
- Year:
- 1 980
- Bibliographic source:
- Mutation Research 77, 109-116.
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The spot test, first described by Iyer and Sybalsky (1958) and later by Ames et al. (1975).
- GLP compliance:
- not specified
- Type of assay:
- other: Spot test
Test material
- Reference substance name:
- Hexachloroiridic acid
- EC Number:
- 241-012-8
- EC Name:
- Hexachloroiridic acid
- Cas Number:
- 16941-92-7
- Molecular formula:
- Cl6Ir.2H
- IUPAC Name:
- hexachloroiridium(2-);hydron
- Test material form:
- not specified
- Details on test material:
- - Name of test material (as cited in study report): H2IrCl6 (name & CASRN not reported)
- Analytical purity: "Of the highest purity commercially available" in Japan.
Constituent 1
Method
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Species / strain / cell type:
- S. typhimurium TA 1538
- Species / strain / cell type:
- E. coli, other: B/r WP2 try- and WP2 hcr- try-
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 0.001-10 M
- Details on test system and experimental conditions:
- Bacterial strains were spread on plates containing broth-enriched agar. Filter-paper disks containing the test substance were placed onto the plates. Revertant colonies around the disk were counted. Reversion assays with the test substance in liquid were also carried out with the two E.coli strains.
Results and discussion
Test results
- Species / strain:
- other: all strains
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative without metabolic activation
In a limited assay (Spot test), hexachloroiridic acid failed to induce reverse mutations in bacteria. - Executive summary:
In a limited assay (the spot test), filter paper discs containing hexachloroiridic acid were place onto agar plates containing bacterial strains Salmonella typhimurium TA98, TA100, TA1535, TA1537, TA1538 or Escherichia coli strains B/r WP2 try- and WP2 hcr- try-. Revertant colonies around the discs were counted. Reversion assays with the test substance in liquid were also carried out with the two E.coli strains.
The test substance (at up to 10 M) failed to induce reverse mutations in bacteria.
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