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EC number: 449-160-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 Oct 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study. The study was conducted according to the appropriate EU Method C.7 guideline, and in compliance with GLP.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- - Sample storage conditions before analysis: Immediately after sampling, the samples were cooled to room temperature by running tapwater. Thereafter, each sample was diluted with mobile phase to obtain concentrations within the calibration range.
- Buffers:
- - pH: 4, 7 and 9
- Type and final molarity of buffer: sterile 0.05 M acetate (pH 4), phosphate (pH 7) and borate (pH 9)
- Composition of buffer: pH 4: sodium acetate/acetic acid/Milli-Q water; pH 7: potassium dihydrogen phosphate/sodium; pH 9: boric acid/potassium chloride/sodium hydroxide/Milli-Q water - Details on test conditions:
- TEST SYSTEM
- Type, material and volume of test flasks: Vessels, glass and 50 mL
- Sterilisation method: filter-sterilized through a 0.2 µm membrane filter and transferred into sterile glass vessels
- Lighting: darkness
- Measures to exclude oxygen: To exclude oxygen, nitrogen gas was bubbled through the solution for approximately 5 minutes
- Details of traps for volatile, if any: The vessels were sealed with a septum-crimpcap
TEST MEDIUM
- Volume used/treatment 50 mL
- Kind and purity of water: Tap water purified by reversed osmosis and subsequently passed over activated carbon and ion-exchange cartridges
- Preparation of test medium: 500 µL of stock solution of A-1160 (methanol stripped) in acetonitrile was added to the sterile buffer solution, resulting in a test substance concentration of 134 mg/L. After preparation, the test solutions at pH 4, pH 7 and pH 9 were placed in a thermostatically controlled waterbath at 50.0 ± 0.5 °C in the dark. - Duration:
- 2.4 h
- Initial conc. measured:
- >= 109 - <= 119 mg/L
- Duration:
- 2.4 h
- Initial conc. measured:
- >= 43.9 - <= 84.5 mg/L
- Duration:
- 2.4 h
- pH:
- 9
- Initial conc. measured:
- >= 16.8 - <= 81.6 mg/L
- Number of replicates:
- Two replicates per pH sample.
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- In the preliminary study, the half-life time was found to be under aqueous solutions buffered at 25 °C < 1 day at pH 4, pH 7 and pH 9. For component M2 at pH 7, a decrease in concentration of 46% was observed. A second test at pH 7 was comparable with the first results (i.e. 44%).
- Transformation products:
- not measured
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- < 12 h
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- < 12 h
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- < 12 h
- Conclusions:
- Based on these results, it was concluded that A-1160 (methanol stripped) is hydrolytically unstable in aqueous solutions buffered at pH 4, pH 7 and pH 9.
Reference
The concentration of A·1160 (methanol slripped) was determined using an LC·MS·MS
analytical method. Quantitative analysis ware based on the three major components (Notox
identification M2, M3 end M4) in A·1160 (methanol stripped).
M2: H2N-(C=O)-NH-(CH2)3Si(OCH2CH3)2(OCH3)
M3: H2N-(C=O)-NH-(CH2)3Si(OCH2CH3) (OCH3)2
M4: H2N-(C=O)-NH-(CH2)3SI(OCH3)3
Table 1: Results of the hydrolysis of A-1160 (methanol stripped) at 50 ± 05 °C |
||||||
pH Code |
Measured pH value |
Component |
Concentration test substance (mg/L)1after |
|||
0 hours |
2.4 hours |
5 days |
||||
4 |
4.002/ 4.003 |
M2 |
119 |
0 |
(0%)4 |
-5 |
M3 |
114 |
0 |
(0%)4 |
-5 |
||
M4 |
109 |
0 |
(0%)4 |
-5 |
||
7 |
7.032/ 7.013 |
M2 |
84.5 |
45.4 |
(54%)4 |
-5 |
M3 |
69.8 |
12.7 |
(18%)4 |
-5 |
||
M4 |
43.9 |
0 |
(0%)4 |
-5 |
||
7 |
7.062/ 7.043 |
M2 |
1647 |
92.56,7 |
(56%)4 |
-5 |
M3 |
1657 |
34.2 |
(21%)4 |
-5 |
||
M4 |
1577 |
1.86 |
(1%)4 |
-5 |
||
9 |
8.972/ 8.983 |
M2 |
81.6 |
0 |
(0%)4 |
-5 |
M3 |
52.0 |
0 |
(0%)4 |
-5 |
||
M4 |
16.8 |
0 |
(0%)4 |
-5 |
1mean value of duplicate injections. The maximum deviation between the response was < 10%
2At t = 0 hours.
3At t = 2.4 hours.
4Relative concentration.
5Not analysed.
6Maximum deviation between the response was 14.5% for M2 and 13.0% for M4.
7Extrapolated from regression line
Description of key information
Half-life at pH 4, 7 and 9 was < 12 h (EU Method C.7), RL1
Key value for chemical safety assessment
Additional information
The determination of the hydrolysis rate of Ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (116912-64-2) as a function of pH was based on EU Method C.7 and GLP (NOTOX, 2000a). The concentration of test item was determined using an LC-MS-MS analytival method. Quantitative analysis were based on the three main components M2: H2N-(C=O)-NH-(CH2)3 -Si(OCH2CH3)2(OCH3); M3: H2N-(C=O)-NH-(CH2)3-Si(OCH2CH3)(OCH3)2; M4: H2N-(C=O)-NH-(CH2)3-Si(OCH2CH3)3. At pH 4 and pH 9, a decrease in concentration > 50% was observed after 2.4 hours for each component (half-life time at 25 °C < 1day). At pH 7 a decrease in concentration > 50% was observed after 2.4 hours for components M3 and M4 (half-life time at 25 °C < 1 day). For component M2 at pH 7, a decrease in concentration of 46% was observed. To confirm this result, a second test at pH 7 was performed. The decrease in concentration of component M2 was comparable with the first test results (i.e. 44%).
Based on these results, it was concluded that Ureidopropyltrialkoxysilane, mixed methoxy and ethoxy esters (116912-64-2) is hydrolytically unstable in aqueous solutions buffered at pH 4, pH 7 and pH 9.
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