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EC number: 237-523-0 | CAS number: 13825-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1991-01-30 to 1991-02-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study reliable without restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- adopted 24 Feb. 1987
- Deviations:
- no
- GLP compliance:
- yes
- Remarks:
- The study report states that the study was conducted in compliance with OECD Principles of Good Laboratory Practice (Bundesanzeiger Nr. 42a, of the 2nd of March 1983 and Bundesgesetzblatt, Part I, of the 22nd of March 1990.
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Titanium oxide sulphate
- EC Number:
- 237-523-0
- EC Name:
- Titanium oxide sulphate
- Cas Number:
- 13825-74-6
- Molecular formula:
- O5STi
- IUPAC Name:
- Titanium(IV) Oxysulfate
- Details on test material:
- - Name of test material (as cited in study report): Titanium oxide sulfate
- Physical state: brown liquid
- Stability under test conditions: Analytic investigation regarding the stability of the test substance in the vehile showed that the test substance was stable during the exposure period.
- Storage condition of test material: closed bottle
No further significant information on test material was stated.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeder Winkelmann, Borchen
- Age at study initiation: according to the weight of the rat, the rats were ca. 8 (males) to 10 (females) weeks old
- Weight at study initiation: males had an average weight of 187 g; females had an average weight of 171 g
- Fasting period before study: Approx. 16 hr
- Housing: Groups of 5 in type III macroloncages with dust free wood granulate (Ssniff, Soest/Westfalen).
- Diet (ad libitum): fixed-formula standard diet Altromin 1324 pellets 8Altromin GmbH and Co KG, Lage)
- Water (ad libitum): drinking water
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 +/- 2 °C
- Relative humidity: approx. 50 +/- 10%
- Air changes: approx. 10/hr
- Photoperiod (hrs dark / hrs light): 12/12
No further significant information on test animals was stated.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
No further significant information on oral exposure was stated. - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: On the day of application the animals were observed a couple of times. During the observation period the animals were observed twice each day (once on weekends and holidays). The animals were weighed directly before test substance administration, after one week and at the end of the observation period.
- Necropsy of survivors performed: Yes.
- Other examinations performed: The beginning, duration and intensity of clinical signs were recorded and if needed dead animals were removed. All animals that died during the experiment and animals that were killed with diethyl ether anaesthesia in the end of the experiment were pathological examined.
No further significant information on study design was stated. - Statistics:
- Since only one dose level was used the LD50 was estimated.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: The LD50 was exactly determined. See Statistik above.
- Mortality:
- One female rat died 4 hours after dosing of the test substance.
- Clinical signs:
- other: Rats dosed with 2000 mg/kg bw suffered from piloerection and apathy. The symptoms were of minimal intensity to medium intensity and were observed about 30 minutes after dosing of the test substance. Generally, the symptoms were seen for up to 8 hours
- Gross pathology:
- The female, which died during the study, showed in some places of the fundus of the stomach blackish coloured stomach mucosa. The mucosa of the small intestine was reddened. In all other animals nothing was found during the pathological examination.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A LD50 > 2000 mg/kg bw was stated for male and female rats. Titanium oxide sulfate was considered as nontoxic. According to the directive 67/584/EWG and regulation (EC) 1272/2008 (CLP) titanium oxide sulfate does not need to be classified.
- Executive summary:
This study on acute oral toxicity with target chemical titanium oxide sulphate followed the protocol as given by OECD Guideline 401. Propylene glycol was used as vehicle. The LD50 was determined to > 2000 mg/kg bw. According to the EU classification systems CLP and DSD no classification of the substance as to its acute oral toxicity properties applies.
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