Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-523-0 | CAS number: 13825-74-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
Titanium oxide sulphate (TiOSO4) In contact with water is hydrolysed very fast to sulphuric acid and TiO2.There is no potential of bioaccumulation of sulfate. TiO2 particles might accumulate in the lungs and the lymphatic tissues if exposure via the in halation overpowers the clearance mechanism. As this is only to be expected at very high exposure levels, bioaccumulation is not expected under normal exposure conditions.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
Summary of the toxicokinetic assessment of Frère 2011:
Titanium oxide sulphate (TiOSO4) is a colourless white solid that is usually produced as a powder. In contact with water titan oxide sulfate is hydrolysed very fast to sulphuric acid and TiO2. Therefore the toxicokinetic assessment focuses on these two species. The assessment does not cover the discussion on the toxicokinetic of TiO2 nanoparticles.
Sulphate stemming from buffering of the sulphuric acid to neutral pH can be absorbed via specialised transport systems in the lungs and the intestine. Skin penetration of ionic substances like sulphate is usually very low, but might be increased through the caustic action of the substance in contact with wet material.
TiO2 particles are poorly soluble so no significant absorption of titanium ions is expected via any of the possible exposure routes. 28 d treatment of rats with a very high dose of 24g/kg bw/d of TiO2 via gavage did not lead to any signs of toxicity indicating that the uptake via the oral route is negligible. Skin penetration of TiO2 particles of the micrometre scale is very unlikely due to the barrier function of the skin. In the lung most TiO2 particles will be transported to the intestine via the mucociliar clearance mechanism. Residual particles are phagocytosed by macrophages and shuttled via the lymphatic system to the liver where they are excreted via the bile. So while they are incorporated they are not truly systemically available. Accordingly they are not metabolised. As an essential ion, absorbed sulphate stemming from sulphuric acid will be included in the physiological processes distributed throughout the organism accordingly, possibly subjected to redox metabolism and finally excreted via the urine.
Therefore there is no potential of bioaccumulation of sulfate. TiO2 particles might accumulate in the lungs and the lymphatic tissues if exposure via the in halation overpowers the clearance mechanism. As this is only to be expected at very high exposure levels, bioaccumulation is not expected under normal exposure conditions.
Supporting information:
This assessment is in line with the statement on the toxicokinetic of TiO2 in the respective REACH dossier of 2011, and is further being supported by the studies of Landford-Pollard 2003 and Midlander 2007.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.