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EC number: 204-818-0 | CAS number: 126-99-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Genetic toxicity
The genetic toxicity of chloroprene, and its metabolites has been extensively investigated over many years in guideline and pre-guideline studies in vitro (using bacterial and mammalian test systems) and in vivo. Both negative and positive mutagenic responses, in the presence and absence of metabolic activation have been reported in mutagencity tests using chloroprene in bacterial. Although chloroprene has given positive results in some bacterial mutagenesis assays, it has been propsed that the mutagenic effects seen in these studies may arise from reactive metabolites formed by microsomal mixed function oxidases or from the breakdown products of aged chloroprene. The primary metabolite of chloroprene, 1-CEO, was mutagenic to 4 strains of S. typhimurium in a bacterial reverse mutation assay.While a reactive metabolite of chloroprene, 1-CEO may induce mutations in vitro in bacterial strains (Himmelsteinet al. 2001a), neither the administration of chloroprene (Drevon and Kuroki1979) nor this epoxide metabolite (Himmelsteinet al. 2001a) was genotoxic or mutagenic in in vitro mammalian cell gene mutation or micronucleus cell assays, respectively, in Chinese hamster V79 cells.
Chloroprene was not genotoxic when tested in vivo (several pre-guideline and published studies: NTP 1998c,d,e, Willems 1978, Immel 1978a,b,c. These data indicate that the reactive metabolites formed from chloroprene are effectively detoxified in vivo in the concentration ranges studied.
Overall it is concluded that chloroprene is no in vivo mutagen. Recent findings on K-ras proto-oncogen mutations in lung and Herderian gland neoplasms were indicative for mutagenic events involved (Sills 1999) but not conclusive, as K-ras mutations might be associated with other processes (e. g. cell proliferation secondary to cytotoxicity or selection for pre-existing mutations). For these reasons, no classifiaction for genotoxicity or mutagenicity for chloroprene is indicated.
Short description of key information:
The genetic toxicity of chloroprene, and its metabolites has been extensively investigated over many years in guideline and pre-guideline studies in vitro (using bacterial and mammalian test systems) and in vivo. Both negative and positive mutagenic responses, in the presence and absence of metabolic activation have been reported in mutagencity tests using chloroprene in bacterial. Although chloroprene has given positive results in some bacterial mutagenesis assays, it has been propsed that the mutagenic effects seen in these studies may arise from reactive metabolites formed by microsomal mixed function oxidases or from the breakdown products of aged chloroprene. The primary metabolite of chloroprene, 1-CEO, was mutagenic to 4 strains of S. typhimurium in a bacterial reverse mutation assay. While a reactive metabolite of chloroprene, 1-CEO may induce mutations in vitro in bacterial strains (Himmelstein et al. 2001a), neither the administration of chloroprene (Drevon and Kuroki1979) nor this epoxide metabolite (Himmelstein et al. 2001a) was genotoxic or mutagenic in in vitro mammalian cell gene mutation or micronucleus cell assays, respectively, in Chinese hamster V79 cells.
Chloroprene was not genotoxic when tested in vivo (several pre-guideline and published studies: NTP 1998c,d,e, Willems 1978, Immel 1978a,b,c). These data indicate that the reactive metabolites formed from chloroprene are effectively detoxified in vivo in the concentration ranges studied.
Chloroprene is not classified in europe as mutagen.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Chloroprene is not classified for genotoxicity or mutagencity according to EU classification legislation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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