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EC number: 243-900-0 | CAS number: 20592-85-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Short term toxicity to fish
A reliable 96-hour LC50 value of 160 mg active acid/L has been determined for the effects of ATMP-H on mortality of Salmo gairdneri (now known as Oncorhynchus mykiss).
A 96-hour LC50 value of >282 mg/L has been determined for the effects of ATMP-xNa salt on the mortality of the marine fish Cyprinodon variegatus.
Long term toxicity to fish
A 60-day NOEC value of 23 mg active acid/L has been determined for the effects of ATMP-H on growth of the fish O. mykiss. This study represents the only value available for this endpoint.
Short term toxicity to invertebrates
A 48-hour LC50 value of 94 mg active acid/L has been determined for the effects of ATMP-H on mortality of the marine invertebrate Acartia tonsa. This study represents the lowest reliable value available for this endpoint.
A 48-hour EC50 value of 297 mg active acid/L has been determined for the effects of ATMP-H on the immobility of the freshwater flea Daphnia magna.
Long term toxicity to invertebrates
A 28-day NOEC value of ≥ 25 mg active acid/L has been determined for the effects of ATMP-H on adult survival and reproduction of D. magna. The study represents the lowest reliable value available for this endpoint.
A 96-hour NOEC value of 96 mg active acid/L has also been determined for the effects of ATMP-H on the growth of the eastern oyster Crassostrea virginica.
Toxicity to algae and cyanobacteria
72-hour EC50 and NOEC values of 80 and 40 mg active acid/L respectfully, have been determined for the effects on ATMP-H on the growth rate of Skeletonema costatum. This value represents the lowest reliable value available for this endpoint. Another study determined a 96-hour EC50 value 12.39 mg active acid/L based on biomass of Pseudokirchneriella subcapitata, however, this value was not deemed reliable and is not used as the key value for this endpoint.
Additional information
- ATMP is present as ATMP-H or one of its ionised forms. The degree of ionisation depends upon the pH of the media and not whether ATMP (3-5K) salt, ATMP (3-5Na) salt, ATMP-H (acid form), or another salt was used for dosing.
- Disassociated potassium, sodium or ammonium cations. The amount of potassium or sodium present depends on which salt was dosed.
- It should also be noted that divalent and trivalent cations would preferentially replace the sodium or potassium ions. These would include calcium (Ca2+), magnesium (Mg2+) and iron (Fe3+). These cations are more strongly bound by ATMP than potassium, sodium and ammonium. This could result in ATMP-dication (e.g. ATMP-Ca, ATMP-Mg) and ATMP-trication (e.g. ATMP-Fe) complexes being present in solution.
The acid, sodium, potassium and ammonium salts in the ATMP category are freely soluble in water. The ATMP anion can be considered fully dissociated from its sodium, potassium or ammonium cations when in dilute solution. Under any given conditions, the degree of ionisation of the ATMP species is determined by the pH of the solution. At a specific pH, the degree of ionisation is the same regardless of whether the starting material was ATMP-H, ATMP.4Na, ATMP.7K or another salt of ATMP.
Therefore, when a salt of ATMP is introduced into test media or the environment, the following is present (separately):
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