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EC number: 417-070-7
CAS number: 151006-62-1
1-DODECENE TRIMER, HYDROGENATED; ALKANE 4
SKIN REACTIONS IN TEST ANIMALS AT CHALLENGE
CONCENTRATIONS: 100% AND 75% w/v VEHICLE: DRIED ARACHIS OIL B.P.
Skin Reactions (Hours after Removal of Dressing)
a guinea pig maximization test (Driscoll, R., 1995; Klimisch score = 1),
38 albino female Dunkin Hartley guinea pigs were dermally exposed to
1-dodecene dimer, hydrogenated. Following a preliminary screening study,
concentrations of 25% w/v in dried Arachis Oil B.P. were selected for
the intradermal injection during the induction phase. Topical induction
was also conducted in this study and the test material was administered
as supplied. For the challenge phase concentrations of 100% (undiluted)
and 50% w/v in dried Arachis Oil B.P. were topically administered to the
guinea pigs two weeks post topical induction. Animals were observed
daily for signs of ill health and toxicity. Body weights were recorded
individually and dermal reactions to intradermal injections and topical
applications during induction and challenge were also observed for.
Challenge sites were evaluated 24 and 48 hours after removal of patches.
was no adverse treatment-related effect seen in the animals through the
study period. Bodyweight
gains of guinea pigs in the test group, between Day 0 and Day 24, were
comparable to those observed in the control group animals over the same
period. Well-defined erythema was noted at the intradermal induction
sites of all test group animals at the 24 and 48-hour observations. Very
slight erythema was noted at the intradermal induction sites of seven
control group animals at the 24-hour observation and persisted at the
intradermal induction sites of six control group animals at the 48-hour
observation. Post topical induction, well-defined erythema was noted at
the induction sites of three test group animals with very slight
erythema noted at the induction sites of seventeen test group animals at
the 1-hour observation. Bleeding at the intradermal injection sites was
noted in three test group animals. Very slight erythema was noted at the
induction sites of six test group animals at the 24-hour observation. No
skin reactions were noted at the treatment sites of the control group
animals at the 1 and 24-hour observations. At challenge, for the
undiluted test material, no skin reactions were noted at the challenge
sites of the test group animals at the 24 and 48-hour observations. Very
slight erythema was noted at the challenge site of one control group
animal at the 24-hour observation. No skin reactions were noted in the
control group animals at the 48-hour observation. At challenge, for the
75% w/v concentration, no skin reactions were noted at the challenge
sites of the test and control group animals at the 24 and 48-hour
dimer, hydrogenated produced a sensitization rate of 0% (0/20). Based on
the results of this study, 1-dodecene dimer, hydrogenated is not
considered to be a skin sensitizer in the guinea pig.
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