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EC number: 417-070-7
CAS number: 151006-62-1
1-DODECENE TRIMER, HYDROGENATED; ALKANE 4
In accordance with Column 2 Adaptation as stated in REACH Regulation (EC) No. 1907/2006 (section 9.3.2, Annex IX) the bioaccumulation study does not need to be conducted if the substance has a low potential to cross bioolgical membranes. The optimal range for diffusive uptake is log Kow -1 to 4 according to ECHA guidance chapter R.7c , see toxicokinetic assessment). Moderate log P values (between -1 and 4) are favourable for absorption by passive diffusion. Any lipophilic compound may be taken up by micellular solubilisation but this mechanism may be of particular importance for highly lipophilic compounds (log P >4), particularly those that are poorly soluble in water (1 mg/l or less) that would otherwise be poorly absorbed. The submission substance has a log Kow >10 and is therefore not expected to bioaccumulate.Infact, for reasons mentioned above, members of this category are not expetced to bioaccumulate.
Experimental data on Kow are available for several
members of this category. For the alkane with CAS No. 68649-11-6 log Kow
is measured as >6.5 (Walker and Mullee, 2006) and > 4.82 (Hogg and
Bartlett, 1995). For CAS No. 68649-12-7, experimental data measures log
Kow as > 5 (Howard, 1982), > 7.6 (Seary, 2000) and > 3.87 (Hogg and
Bartlett, 1995). For CAS No. 68037-01-4 an experimental value of >6.5
(Walker and Mullee, 2006) is given. As the majority of the experimental
log Kow for substances in this category are greater than 4.5 this
indicates that an estimate of the bioaccumulation potential is required.
Non-polar substances have been shown to have a linear
relationship between log Kow and BCF in the log Kow range 1 -6. However,
at log Kow >6 a decreasing relationship is observed. ECHA’s Guidance on
information requirements and chemical safety assessment - Part C: PBT
Assessment (2008) states that the aquatic BCF of a substance is probably
lower than 2000 L/kg if the calculated log Kow is higher than 10. All of
the experimental log Kow values for substances in this category are
unbounded due to limitations of the experimental method, so do not allow
us to conclude if the log Kow is greater than 10. Calculated partition
coefficients have been obtained from EPIWEB 4.0 (USEPA, 2008) and SPARC
(Karickhoff et al, 2009) for dec-1-ene dimer, hydrogenated (CAS
68649-11-6) and dec-1-ene trimer, hydrogenated (CAS 157707-86-3) as
these are the only two members of this category being registered as
substances with predominantly a single carbon number. The calculated log
Kow for CAS No. 68649-11-6 is 10.09 and 11.71 and for CAS No.
157707-86-3 is 14.93 and 17.21 (USEPA, 2008 and Karickhoff et al, 2009
respectively). All of the calculated log Kow values are greater than 10.
There is a clear trend of increasing log Kow with
increasing carbon number in the alkanes and olefins. Dec-1-ene dimer
hydrogenated (CAS 68649 -11 -6) is the category member with the lowest
carbon number, and therefore will be the category member with the lowest
partition coefficient. This therefore indicates that the calculated log
Kow of all category members would be >10. As QSAR models do not have
experimental data in this Kow range the reliability of modelled Kow
values > 10 is not known. However, as two models indicate a log Kow >10
for the category member with the lowest carbon number we can conclude
that members of this category are unlikely to be bioaccumulative and
therefore that conducting a study to determine an experimental BCF is
not scientifically justified.
In addition, the expert paper (Girling 2007)
on structural analogue Alkane 4 concluded that the BCF of Alkane 4 will
be below 10 and that it will not therefore meet the criterion of BCF
>5000 for being considered very bioaccumulative (vB) or the lesser
criterion of BCF >2000 for being considered bioaccumulative (B). This
expert paper further supports that Alkane 6 is not expected to
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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