Dodecanoic acid, 2,2-dimethyl-3-oxopropyl ester

Endpoint summary

Additional information

Stability

The performance of hydrolysis as a function of pH is scientifically unjustified.

Regulation (EC) No 1907/2006 (REACH), Annex VIII, Sect. 9.2.2.1, Col. 2, states as follows:

9.2.2.1. The study does not need to be conducted if:

– the substance is readily biodegradable; or

– the substance is highly insoluble in water.

In accordance with column 2 of REACH Annex VIII, hydrolysis as a function of pH was not conducted since the the substance is readily biodegradable and has an estimated low water solubility.

 

Supporting study:

In the course of a study, in which the water solubility of the test substance was determined according to OECD guideline no. 105 and EU method A.16 the hydrolysis of the test substance was clearly observed. The test item reacts with oxygen-free water in approx. 60 minutes to products other than the carbon acid, the latter being a product of the reaction with oxygen. The appearance of new peaks in the GC-chromotograms indicates the appearance of degradation products due to hydrolysis.

 

Biodegradation

Biodegradation in water: screening tests

The biodegradation potential of test item was assessed in CO2 evolution test according to OECD guideline 310B and EU method 4.C. After 28 days degradation of 2,2-Dimethyl-3-lauroyloxy-propanal was 91 %. The degradtion at end of the 10-day-window was 74 %.

 

Biodegradation in water and sediment: simulation tests

The performance of simulation tests for biodegradation in water and sediment is scientifically unjustified.

Regulation (EC) No 1907/2006 (REACH), Annex IX, Sect. 9.2.1.2 and Sect. 9.2.1.4, Col. 2, states as follows:

“9.2.1.2/9.2.1.4: The study need not to be conducted:

– the substances is highly insoluble in water; or

– the substance is readily biodegradable.

and

- if the substance is readily biodegradable; or

– if direct and indirect exposure of sediment is unlikely."

In accordance with column 2 of REACH Annex IX, Simulation testing on ultimate degradation in surface water and sediment simulation testing was not conducted since the the substance has an estimated low water solubility and it is hydrolytically unstable and readily biodegradable. Due to the unstable nature of the test substance, it can be assumed that upon contact with water and organic matter, the test item undergoes rapid degradation resulting in the formation of respective degradation products.

 

Biodegradation in soil

The performance of tests for biodegradation in soil is scientifically unjustified.

Regulation (EC) No 1907/2006 (REACH), Annex IX, Sect. 9.2.1.3, Col. 2, states as follows:

“9.2.1.3: The study need not to be conducted:

- if the substance is readily biodegradable, or

- if direct and indirect exposure of soil is unlikely. ”

In accordance with column 2 of REACH Annex IX, Soil simulation testing was not conducted as the substance is readily biodegradable. Due to the hydrolytically unstable nature of the test substance, it can be assumed that upon contact with soil and organic matter, the test item undergoes rapid degradation resulting in the formation of respective degradation products.

 

Bioaccumulation

The performance of bioaccumulation in aquatic species, preferably fish is scientifically unjustified.

Regulation (EC) No 1907/2006 (REACH), Annex IX, Sect. 9.3.2, Col. 2, states as follows:

9.3.2. The study need not be conducted if:

– the substance has a low potential for bioaccumulation (for instance a log Kow < 3) and/or a low potential to cross biological membranes; or

– direct and indirect exposure of the aquatic compartment is unlikely.

In accordance with column 2 of REACH Annex IX, bioaccumulation in aquatic species, preferably fish was not conducted since the substance is considered to have no bioaccumulation potential. Using EPIWIN 4.1 a BCF of 104.5 L/kg wet-wt (Log BCF = 2.019) was calculated indicating no bioaccumulative potential. Due to the hydrolytically unstable nature of the test substance, it can be assumed that upon contact with water and organic matter, the test substance undergoes rapid degradation resulting in the formation of respective degradation products.

 

Transport and distribution

The performance of simulation tests for adsorption/desorption screening is scientifically unjustified.

Regulation (EC) No 1907/2006 (REACH), Annex IX, Sect. 9.3.3, Col. 2, states as follows:

9.3.3. The study does not need to be conducted if:

– based on the physicochemical properties the substance can be expected to have a low potential for adsorption (e.g. the substance has a low octanol water partition coefficient); or

– the substance and its relevant degradation products decompose rapidly.

In accordance with column 2 of REACH Annex IX, simulation tests for adsorption/desorption screening was not conducted since due to the hydrolyically unstable nature of the test substance, it can be assumed that upon contact with water and organic matter, the test item undergoes rapid degradation resulting in the formation of respective degradation products. Furthermore, the test substance is readily biodegradable and rapid decomposition is expected.