Registration Dossier

Administrative data

First-aid measures

Contact with eyes : wash immediately with large amounts of water or normal saline. Keep eyelid open with the finger. Get medical advice.

Contact with skin : remove contaminated clothes and shoes immediately. Wash affected area with soap or mild detergent and large amount of water until no evidence of substance remains. Get medical advice if adverse symptoms will appear.

Ingestion : if swallowed wash mouth with water provided person if conscious. Get medical advice.

Inhalation : avoid breathing dusts that might be generated by handling of the product. Remove the person from the exposed area to fresh air immediately. Get medical advice if adverse symptoms will appear.

Fire-fighting measures

Suitable extinguishing means: regular foam, CO2, dry powder, water spray.

Mean of extinguishing NOT to be used: not known.

Known hazards caused by combustion: thermal decomposition or combustion may generate toxic and hazardous fumes of CO, CO2 and NO2.

In case of fire: Evacuate area. Wear full protective clothing and self-contained breathing apparatus approved NIOSH/MSHA (or equivalent) as appropriate for specific fire conditions.

Accidental release measures

Personal precautions: wear suitable protective clothing, eye/face protection goggles, mask complete of suitable filter protection. Avoid dust formation. Avoid breathing vapours, dust, gas. Mantain a well-ventilated area. Evacuate area.

Environmental precautions: collect and clean with plenty of water. Send to the storage waiting for disposal procedures. Mantain a well-ventilated area. Do not let the product enter drainage system, surface and ground-water and soil. Contact local authorities in case of environmental release.

Cleaning procedure to recover spilled material: Recover the substance for suction or other mechanical means and wash the area with plenty of water and detergents. Wear suitable protective clothing. Store the material into a company that specializes pending disposal. Containers must be cleaned up and disposed.

Handling and storage

The substance is chemically transformed into another intermediate in the synthesis of a final Active Pharmaceutical Ingredient.

The substance must be handled in ventilated environment or with the appropriate local air extraction; minimize dust formation and avoid accumulation on surfaces; use antistatic equipment and clothing and prevent dust contact with possible ignition sources; avoid contact with eyes, skin and clothing. Remove contaminated clothes and wash thoroughly after handling.

Use container tightly closet and resistant, away from moisture and sunlight. Avoid contact with air and light. Properly label containers in case of pouring and clean external container surfaces with proper detergents and /or solvents.


Transport information

Land transport (ADR/RID)

UN number:
3077
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Class:
9
Packaging group:
III
Labels:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone)
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Inland waterway transport (ADN(R))

UN number:
36077
Shippingopen allclose all
Class:
9
Packaging group:
III
Labels:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone)
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Marine transport (IMDG)

UN number:
3077
Chemical name:
(3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone)
Class:
9
Packaging group:
III
Labels:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone)
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Air transport ICAO/IATA

UN number:
3077
Chemical name:
(3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone)
Class:
9
Packaging group:
III
Labels:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. ((3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone)
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Eye and Face protection: Safety goggles
Respiratory protection: Dust mask with approved dust filter P1. Use only devices approved by the Competent Authorities such as NIOSH (USA) and CEN (EU)
Hands protection: Protective gloves as for the EN 374/US739. Make the choice of the glove material on consideration of the penetration times, rates of diffusion and degradation. r
Other, body protection: Select the suitable protective equipment based on the activity of use and possible exposure.

Stability and reactivity

Stable under normal storage conditions.

Disposal considerations

National laws on disposal must be considered, local and UE requirements for wastes recycling must be respected.