Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April - June 2014
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP Study
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2014
Report Date:
2014

Materials and methods

Test guidelineopen allclose all
Qualifier:
equivalent or similar to
Guideline:
EU Method A.8 (Partition Coefficient)
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
GLP compliance:
yes (incl. certificate)
Type of method:
HPLC method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
XU-18838.00: lot# JHY 1307
Purity: 98.9%

Results and discussion

Partition coefficientopen allclose all
Type:
Pow
Partition coefficient:
> 3 160 000
Remarks on result:
other: Temperature was not monitored, but it was "room temperature". The pH was not measured because there is no ionisable group in the molecule.
Type:
log Pow
Partition coefficient:
> 6.5
Remarks on result:
other: Temperature was not monitored, but it was "room temperature". The pH was not measured because there is no ionisable group in the molecule.

Applicant's summary and conclusion

Conclusions:
A preliminary assessment of the partition coefficient was calculated using the US EPA software KOWWIN v1.67a and the logKow value was found to be 11.59. An HPLC study was then made and only a lower limit for logKow > 6.5 could be determined.