Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 626-470-2
CAS number: 5405-40-3
- Table 1: Preliminary Irritation Study, Skin Reactions after
24 hours after injection
48 hours after injection
Table 2: Preliminary Irritation Study,Skin Reactions after
24 hours after exposure
48 hours after exposure
- Table 3: Induction Readings
Intradermal injection (Day 3) A
Epidermal exposure (Day 10)
A: 1:1 Mixture of FCA and water for injection.
Skin effects intradermal injections:
E: Erythema (grade)
N: Signs of necrosis (mm in diameter)
- Table 4: Challenge Readings
#: Test substance concentration.
*: Water (Milli-U)
RS-Pantolactone (named D,L-Lactone in the study report) was tested
for its skin sensitization potential according to OECD 406 following the
GPMT test setting, EC Commission Directive 96/54/EC, Part B.6, "Skin
Sensitisation" (1996), EPA OPPTS 870.2600 "Skin Sensitisation" (2003)
and JMAFF: Japanese Test Guidelines (2000) including the most recent
partial revisions, and was based on the method described by Magnusson
and Kligman, "Allergic Contact Dermatitis in the Guinea Pig -
Identification of Contact Allergens" (1970).
Test substance concentrations selected for the main study were
based on the results of a preliminary study.
In the main study, ten experimental animals were intradermally
injected with a 5% concentration and epidermally exposed to a 50%
concentration. Five control animals were similarly treated, but with
vehicle alone (water). Injection sites treated with FCA showed transient
erythema of grades 1 to 2 in both groups. Approximately 24 hours before
the epidermal induction exposure all animals were treated with 10% SDS.
Two weeks after the epidermal application all animals were challenged
with a 50% test substance concentration and the vehicle.
There was no evidence that RS-Pantolactone had caused skin
hypersensitivity in the guinea pig, since no responses were observed in
the experimental animals in the challenge phase.
This result indicates a sensitisation rate of 0 per cent.
By expert judgment it is conclude that L-Pantolactone is not sensitising
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again