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EC number: 626-470-2
CAS number: 5405-40-3
The fluorescein retention and corneal opacity of ICE before treatment:
Flurorescein retention score before treatment
Corneal opacity before treatment
Positive control -01
Positive control -02
Positive control -03
Negative control -01
The fluorescein retention and
corneal opacity of ICE after treatment:
Flurorescein retention score 30 min after treatment
Corneal opacity after treatment
Observation of other adverse
adverse morphological effect was observed in all the seven
ICEs during the observation period.
For test substance, the mean maximum opacity score after treatment is
1.7 (Class III); the mean fluorescein retention score at 30 min after
treatment is 2.0 (Class III). No adverse morphological effect was
observed during the observation period. Hence, the test substance is not
considered as ocular corrosive or severe irritant.
For positive control substance, the mean maximum opacity score after
treatment is 2.7 (Class IV); the mean fluorescein retention score at 30
min after treatment is 3.0 (Class IV). The corneal opacity of all the
three eyes was >= 2 at 30 min after treatment. Hence, the positive
control substance is considered as ocular corrosive or severe irritant.
For negative control substance, the mean maximum opacity score after
treatment is 0.5 (Class II); the mean fluorescein retention score at 30
min after treatment is 0.5 (Class I). Hence, the negative control
substance is not considered as ocular corrosive or severe irritant.
L-Pantlactone has effects on the eyes (opacity score after treatment is
It can not be distinguished, if the irritating effects are slightly or
The substance will be classified as serious eye damage/eye irritation,
cat 2 (GHS), Irritating, Xi, R36 (DPD) until other test must be taken.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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