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Diss Factsheets
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EC number: 203-354-6 | CAS number: 106-02-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
EU Method C.3, GLP, key study, validity 2:
72h-ErC10 = 0.42 mg/L;
No ErC50 value can be derived for algae.
Key value for chemical safety assessment
- EC10 or NOEC for freshwater algae:
- 0.42 mg/L
Additional information
Four valid studies are available to assess the toxicity of the substance to aquatic algae.
The first study (Caspers, 1996), assessed as the key study, was performed according to EU Method C.3 with GLP statement on the registered substance. Under the conditions of this test, no ErC50 value can be derived for algae either as insufficient toxicity was observed (72h-ErC50 > 0.47 mg/L, the highest tested concentration) but some effects were observed indicating a potential for toxicity close to the solubility limit, with a 72h-ErC10 value based on growth rate at 0.42 mg/L.
The other studies (Scheerbaum, 2005; Dengler, 2005; Sewell, 1995), assessed as supporting studies, were performed according to OECD Guideline 201 and EU Method C.3 with GLP statement on the read-across substance (EC Number: 422-320-3). This supporting substance is considered adequate for read-across purposes (see Iuclid section 13 for justification). No ErC50 value can be derived for algae because either insufficient toxicity was observed or effects were observed at concentrations greater than the solubility limit. However, some mild effects were observed, especially in the first day of the study although this diminished over the study period, indicating a mild potential for toxicity close to the solubility limit (worst case 72h-ErC10 value at 0.73 mg/L), but it is not clear if these effects are physical or due to actual toxicity of the substance. It is not possible to maintain this concentration under the conditions of an algae study due to degradation and adsorption of the substance during the test. No further algae studies are required.
In conclusion, according to the key study performed on the registered substance, no ErC50 can be derived for algae but the 72h-ErC10 at 0.42 mg/L is used as the key value, greater than the solubility limit of the registered substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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