Registration Dossier
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EC number: 200-657-5 | CAS number: 67-51-6
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The biodegradability of 3,5-Dimethylpyrazole was determined in a key study (Kelly & Clayton, 2003) performed in line with GLP and to the standardised guidelines OECD 1301 A and EU method C.4 A. The test material was determined to be not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Kelly & Clayton (2003) has been provided as the key study where the biodegradability of the test material was assessed in a DOC die away test. The study was performed to GLP and standardised guidelines and had thus been assigned a reliability score of 1 using the principles for assessing data quality as set out in Klimisch (1997).
Under the conditions of the test, the test material was determined to be not readily biodegradable. The percentage degradation observed at 28 days, was comparable to that of the abiotic control, 42.8% and 47.2%, respectively. Thus, the observed reduction of DOC from the test vessel cannot be attributed to the microbial inoculum and is considered to be a result of hydrolytic instability. The test material did not have an inhibitory effect on the inoculums, shown by the toxicity control, 38.7% degradation was achieved by Day 4. The reference substance was determined to be readily biodegradable, indicating the acceptability of the inoculum activity and validity of the test procedure.
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