Registration Dossier
Registration Dossier
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EC number: 413-890-4 | CAS number: 82469-79-2
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 413-890-4
- EC Name:
- -
- Cas Number:
- 82469-79-2
- Molecular formula:
- C28H50O8
- IUPAC Name:
- 1,2,3-trihexyl 2-(butanoyloxy)propane-1,2,3-tricarboxylate
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium TA 98, TA 100, TA 1535, TA 1538 strains Escherichia coli strain WP2 uvra (WP2A)
- Metabolic activation system:
- Arochlor 1254 induced S-9 Mix from male SD rats.
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 667 ... 10000 µg/plate
Concentration range in the main test (without metabolic activation): 667 ... 10000 µg/plate - Vehicle / solvent:
- Solvent: ethanol (100%)
- Details on test system and experimental conditions:
- Concentration of the test substance resulting in precipitation: 667 µg/plate
Results and discussion
Test resultsopen allclose all
- Species / strain:
- other: S. typhimurium TA98, TA100, TA1535, TA1537, TA1538
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Species / strain:
- E. coli WP2 uvr A
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not determined
- Vehicle controls validity:
- valid
- Positive controls validity:
- valid
- Additional information on results:
- Observations:
No positive responses seen with any of the tester strains in
the presence or absence of microsomal enzymes.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
Citroflex B-6 did not cause a positive response with any tester strains in the presence and absence of microsomal enzymes prepared from Arochlor-induced rat liver.
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