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Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Study period:
20 March 2017 - 20 March 2017
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 111 (Hydrolysis as a Function of pH)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
Deviations:
no
Qualifier:
according to guideline
Guideline:
EPA OPPTS 835.2120 (Hydrolysis of Parent and Degradates as a Function of pH at 25°C)
Deviations:
no
GLP compliance:
yes
Specific details on test material used for the study:
- Source and lot/batch No.of test material: I16CB1581
- Expiration date of the lot/batch: 04 April 2019
- Purity test date:98,61%
- Storage condition of test material: at room temperature
Radiolabelling:
no
Analytical monitoring:
no
Details on test conditions:
According to the guideline, the concentration of test samples should not exceed half the water solubility of the test item or 0.01 M, whichever is lower. The water solubility of the test item is < 2.00 µg/L. No analytical method was available to support the hydrolysis test at this low concentration level. The test on the hydrolysis of the test item could therefore not be performed.

Positive controls:
no
Negative controls:
no
Transformation products:
not measured
Key result
Remarks on result:
not determinable
Validity criteria fulfilled:
yes
Conclusions:
The hydrolysis as function of pH of T003066 was tested according to OECD 111. According to the guideline, the concentration of test samples should not exceed half the water solubility of the test item or 0.01 M, whichever is lower. The water solubility of the test item is < 2.00 µg/L. No analytical method was available to support the hydrolysis test at this low concentration level. The test on the hydrolysis of the test item could therefore not be performed.

Description of key information

The hydrolysis as function of pH of T003066 was tested according to OECD 111. According to the guideline, the concentration of test samples should not exceed half the water solubility of the test item or 0.01 M, whichever is lower. The water solubility of the test item is < 2.00 µg/L. No analytical method was available to support the hydrolysis test at this low concentration level. The test on the hydrolysis of the test item could therefore not be performed.

Key value for chemical safety assessment

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