Registration Dossier
Registration Dossier
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EC number: - | CAS number: -
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The test item was found to be stable in the preliminary test at pH 4, 7 and 9 at 50 °C. Reaction rate constants and half-lives could not be calculated due to the fact that the test item undergoes no significant hydrolysis. According to the guideline a half-life of > 1 year under environmental conditions can be assumed.
Key value for chemical safety assessment
Additional information
Hydrolysis as a function of pH was determined according to OECD Guideline No. 111 and Council Regulation (EC) No. 440/2008, Method C.7.
The study was conducted with test item concentrations of 20 g/L in buffer solutions at pH 4, 7 and 9 at a test temperature of 50 °C (preliminary test).
Samples were taken at test start (0 hours) and test end (120 hours) and analysed viaultra performance liquid chromatography with mass selective detection (MS/MS)on a reversed phase column using an external standard. Buffer solutions were analysed at test start and test end and indicated no interference with the test item. The analytical method for determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity.
Degradation was calculated as the percentage loss of the test item over the time. In the preliminary test, the test item was found to be stable at pH 4, 7 and 9, respectively. No further testing was deemed necessary as less than 10 % of the applied test item was transformed after 120 hours (5 days) at a temperature of 50 °C and each of the three pH values. Reaction rate constants and half-lives could not be calculated because the test item undergoes no significant hydrolysis. With respect to the guidelines a half-life of > 1 year could be assumed for environmental typical temperature conditions.
Degradation [%] of the test substance at 50 °C after 120 Hours
Hydrolysis Time [hours] |
Degradation [%] |
||
pH 4 |
pH 7 |
pH 9 |
|
120 |
0.00 |
8.15 |
0.00 |
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