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EC number: 813-937-2
CAS number: 111512-60-8
An in vivo bone marrow micronucleus assay was conducted to assess the
potential of HCFO-1224yd(Z) to induce chromosomal aberrations using 5
male rats per group dosed at 0 (negative control), 91,092, 303,640 and
910,920 mg/m3 (15,000, 50,000 and 150,000 ppm respectively)
by nose-only inhalation exposure for 4 hours daily with two-day regimen.
Actual exposure concentrations were 99,618, 315,385 and 925,877 mg/m3
(16,404, 51,934 and 152,463 ppm respectively) as the mean concentrations. It
was not considered that there were environmental changes affected the
study results during the exposure.
One animal in the 303,640 mg/m3 (50,000 ppm) group was found
dead just after the exposure on day 1. The cause of
death was not clear; however, it was considered unrelated to the
exposure of the test substance, because there were neither abnormal
clinical signs nor irregular body weight changes in other animals
including even at the higher dose level during the experimental period.
The frequencies of MNIMEs obtained from all test substance groups were
comparable to that of the negative control group. There
were no statistically significant increases in the values in any test
substance groups even if there were four analyzable animals in the
middle dose group being shorter than the other groups. There
were no adverse effects in the study results to evaluate the
The historical control data at the test facility are shown in Appendix.
The individual incidences of MNIMEs ranged from 0.075% to 0.175% in the
negative control group. These values were within the
laboratory historical control data (Mean ± 2SD = 0.149% ± 0.142%). In
the positive control group, the individual values of MNIMEs were within
the maximum and minimum individual range of the historical positive
control. Additionally, a significant increase in the
frequency of MNIMEs was observed in the positive control group compared
to the negative control group. These control results satisfied the
acceptance criteria of this study and supported the validity of this
It is considered that a chemical treated to a mammalian by inhalation
exposure directly contact with alveolus cells and circulatory blood
around the cells, so that the chemical is estimated to be systemically
exposed to the treated animal.
Based on the results described above, HCFO-1224yd(Z) was judged negative
in the rat bone marrow micronucleus assay and did not have a genotoxic
potential to induce chromosome aberration in vivo under the conditions
employed in this study.
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