Registration Dossier
Registration Dossier
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EC number: 826-544-6 | CAS number: 29118-25-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
For acute toxicity (EC50) in algae, VEGA/ProtoQSAR classification
model predicts the compound as“NON-Toxic” (i.e. LC50 > 10 mg/l),
associated to low reliability. Similarly, VEGA/ProtoQSAR regression
model provides prediction of 128.59 mg/l, thus resulting in agreement
with VEGA/ProtoQSAR classification model (ADI = 0.355). However, both
models reports experimental value as “toxic” for the most similar
compound with SMILES N#CC=CC(F)(F)F. The toxicity of such
compound may be triggered by the triple bond N#C, not present in the
target compound. In any case, we cannot exclude a toxicity for the
target compound based on read-across considerations.
Overall assessment. The predictions for acute toxicity in algae are
consistent among each other, although low reliability is associated to
both predictions and they are not supported by read-across considerations.
The compound of concernmay be not toxicto algae (LC50 > 100 mg/l) but
with a high uncertainty.
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 128.59 mg/L
Additional information
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