Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-173-1
CAS number: -
Observation Period (Day)
animals appeared normal prior to dosing AN
= Appears normal
The purpose of this study was to assess the toxicity of the test article
following a single oral dose to the rat. The results
of the study are believed to be of value in predicting the likely
toxicity in man by the oral route.
Initially, one female Sprague Dawley rat was dosed at 175 mg/kg. No
mortality was observed at 175 mg/kg and dosing continued in another
female at 550 mg/kg. Dosing continued in an
additional female at 2000 mg/kg as per protocol guidelines and then in
one female at 5000 mg/kg. Based on these results
two additional females were dosed at 5000 mg/kg. A
total of 6 females were dosed. Mortality checks were
made once daily. Clinical observations were recorded
prior to dosing, as well at 30 minutes, 4 hours post-dose, and daily
thereafter through Day 15. Body weights were recorded
on the day of dosing (Day 1), and on Days 8 and 15. All
rats were euthanized by CO2asphyxiation and necropsied on Day
doses of 175, 550, 2000 or 5000 mg/kg, no mortality was observed. All
animals appeared normal throughout the study at 175, 550, 2000 and
5000 mg/kg. No
biologically significant effect was seen on body weights on Days 8 and
necropsy revealed no visible lesions in any of the animals at 175, 550,
2000 and 5000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again