Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 701-173-1
CAS number: -
The test substance is covered by the category approach of methylenediphenyl diisocyanates (MDI). Hence, data of the category substances can be used to cover this endpoint. The read-across category justification document is attached in IUCLID section 13.
All substances of the MDI category possess aromatic isocyanate functional groups which are known to rapidly hydrolyse and polymerise to polyurea when added to water. Biodegradation is therefore not a relevant transformation process for the category substances. Nevertheless, biodegradation screening tests for the three boundary substances of the MDI category, 4,4’-MDI, pMDI and 4,4’-MDI/DPG/HMWP have been conducted. When biodegradation studies are conducted on MDI substances, these substances are expected to be rapidly hydrolysed/polymerised to their transformation products (mainly insoluble polyurea) immediately after the initiation of the biodegradation studies. Therefore, the biodegradation study results for MDI substances reflect the biodegradability of their transformation products and not necessarily of the MDI substance constituents themselves. The main common (transformation) compounds (i.e. polyurea) are chemically “inert” and are not expected to be biodegradable in the environment. The minor common (transient) transformation compound MDA is shown in various simulation tests to be not persistent in soil and aquatic/sediment systems. Biodegradability of 4,4’-MDI and 4,4’-MDA mono-ureas was also tested. Both substances were not readily biodegradable.Read-across is used to predict the biodegradability outcome of other MDI substances on the basis that biodegradation is not a relevant pathway for the MDI category substances. This hypothesis is supported with high confidence by reliable biodegradation data available for the three source substances as well as the hydrolysis products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Questo sito web si avvale di cookie affinché possiate usufruire della migliore esperienza sui nostri siti web.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again