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Partition coefficient

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partition coefficient
Type of information:
calculation (if not (Q)SAR)
estimated by calculation
Adequacy of study:
key study
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Conducted at a GLP accredited laboratory
no guideline followed
Principles of method if other than guideline:
Experimental techniques are available for the determination of partition coefficient of a substance or preparation. These are described in EC Test A8 as Shake flask method and HPLC method. However, the A8 test cannot to be carried out because the sample react with water. As a result, an estimation based on calculation is carried out.
GLP compliance:
Type of method:
other: estimated by calculation
Partition coefficient type:
other: by calculation
log Pow
Partition coefficient:
ca. 5.61
Remarks on result:
other: estimated
Details on results:
Estimated Log P (mean) of the test substance prepolymer phase is 5.61
A log Pow value for the substance has been determined. However, given the reactivity of MDI in the aquatic environment and its transient existence in water, the log Pow has little direct relevance to the calculation of its environmental fate and ecotoxicity.

Description of key information

A log Pow value of 5.61 was estimated by calculation for MDI/1,3-BD/DEG/PG.  

Key value for chemical safety assessment

Log Kow (Log Pow):
at the temperature of:
20 °C

Additional information

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