Registration Dossier
Registration Dossier
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EC number: 214-882-1 | CAS number: 1205-30-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 431 (In Vitro Skin Corrosion: Reconstructed Human Epidermis (RHE) Test Method)
- Version / remarks:
- The study was performed in compliance with the following regulations or guidelines:
• OECD Guideline for the Testing of Chemicals No. 431 In Vitro Skin Corrosion: Reconstructed Human EpiDermis (RHE) Test Method (29 July 2016)
• Method B.40bis of Commission Regulation (EC) No 440/2008, of 30 May 2008, laying down test methods pursuant to Regulation (EC) No 1907/2006 of the European Parliament and of the Council on the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 4-chloro-5-sulphamoylbenzoic acid
- EC Number:
- 214-882-1
- EC Name:
- 4-chloro-5-sulphamoylbenzoic acid
- Cas Number:
- 1205-30-7
- Molecular formula:
- C7H6O4NClS
- IUPAC Name:
- 4-chloro-3-sulfamoylbenzoic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
In vitro
Results
- Irritation / corrosion parameter:
- % tissue viability
- Run / experiment:
- Run 1 duration of exposure 3 min
Run 2 duration of exposure 60 min - Value:
- >= 91 - <= 91.7
- Vehicle controls validity:
- not valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item was considered to be non-corrosive to the skin.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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