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EC number: 278-270-6
CAS number: 75627-12-2
An Ames test was performed according to OECD guideline 471 and GLP
principles. The test was performed in two independent experiments (one
direct plate assay and one pre-incubation assay) in presence and absence
C.I. Pigment Red 81:2 was tested up to a dose level of 5000 μg/plate in
both experiments. Precipitation was oberved in the direct plate assay in
all tester strains, in the absence and presence of S9 at and above 1600
μg/plate. In the pre-incubation assay, precipitation was observed in all
tester strains at and above 164 and 512 μg/plate in the absence and
presence of S9, respectively. In the first experiment, no cytotoxicity
and/or mutagenicity was observed at any of the strains. In the second
experiment, a decrease in the number of revertant was observed in tester
strain TA1537 only, in the presence of S9 -mix at and above a dose level
of 512 μg/plate. In the other strains, no cytotoxicity and/or
mutagenicity was observed. Precipitation of the test substance was
observed at the start of the incubation period at the highest
concentration. The negative and strain-specific positive control values
were within the laboratory historical control data ranges indicating
that the test conditions were adequate and that the metabolic activation
system functioned properly.
Based on the results of this study it is concluded that C.I. Pigment Red
81:2 is not mutagenic in the Salmonella typhimurium reverse mutation
assay and in the Escherichia coli reverse mutation assay with or without
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